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SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection.
Cele S, Jackson L, Khoury DS, Khan K, Moyo-Gwete T, Tegally H, San JE, Cromer D, Scheepers C, Amoako D, Karim F, Bernstein M, Lustig G, Archary D, Smith M, Ganga Y, Jule Z, Reedoy K, Hwa SH, Giandhari J, Blackburn JM, Gosnell BI, Abdool Karim SS, Hanekom W; NGS-SA; COMMIT-KZN Team; von Gottberg A, Bhiman J, Lessells RJ, Moosa MS, Davenport MP, de Oliveira T, Moore PL, Sigal A. Cele S, et al. Among authors: khan k. medRxiv [Preprint]. 2021 Dec 17:2021.12.08.21267417. doi: 10.1101/2021.12.08.21267417. medRxiv. 2021. Update in: Nature. 2022 Feb;602(7898):654-656. doi: 10.1038/s41586-021-04387-1 PMID: 34909788 Free PMC article. Updated. Preprint.
Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection.
Ndlovu LN, Peetluk L, Moodley S, Nhamoyebonde S, Ngoepe AT, Mazibuko M, Khan K, Karim F, Pym AS, Maruri F, Moosa MS, van der Heijden YF, Sterling TR, Leslie A. Ndlovu LN, et al. Among authors: khan k. Front Immunol. 2020 Aug 28;11:1872. doi: 10.3389/fimmu.2020.01872. eCollection 2020. Front Immunol. 2020. PMID: 32983107 Free PMC article.
Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma.
Cele S, Gazy I, Jackson L, Hwa SH, Tegally H, Lustig G, Giandhari J, Pillay S, Wilkinson E, Naidoo Y, Karim F, Ganga Y, Khan K, Bernstein M, Balazs AB, Gosnell BI, Hanekom W, Moosa MS; Network for Genomic Surveillance in South Africa; COMMIT-KZN Team; Lessells RJ, de Oliveira T, Sigal A. Cele S, et al. Among authors: khan k. Nature. 2021 May;593(7857):142-146. doi: 10.1038/s41586-021-03471-w. Epub 2021 Mar 29. Nature. 2021. PMID: 33780970 Free PMC article.
T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy.
Lustig G, Cele S, Karim F, Derache A, Ngoepe A, Khan K, Gosnell BI, Moosa MS, Ntshuba N, Marais S, Jeena PM, Govender K, Adamson J, Kløverpris H, Gupta RK, Harrichandparsad R, Patel VB, Sigal A. Lustig G, et al. Among authors: khan k. PLoS Pathog. 2021 Sep 23;17(9):e1009871. doi: 10.1371/journal.ppat.1009871. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34555123 Free PMC article.
HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave.
Karim F, Gazy I, Cele S, Zungu Y, Krause R, Bernstein M, Khan K, Ganga Y, Rodel H, Mthabela N, Mazibuko M, Muema D, Ramjit D, Ndung'u T, Hanekom W, Gosnell B; COMMIT-KZN Team; Lessells RJ, Wong EB, de Oliveira T, Moosa MS, Lustig G, Leslie A, Kløverpris H, Sigal A. Karim F, et al. Among authors: khan k. Elife. 2021 Oct 5;10:e67397. doi: 10.7554/eLife.67397. Elife. 2021. PMID: 34608862 Free PMC article.
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy.
Greaney AJ, Starr TN, Eguia RT, Loes AN, Khan K, Karim F, Cele S, Bowen JE, Logue JK, Corti D, Veesler D, Chu HY, Sigal A, Bloom JD. Greaney AJ, et al. Among authors: khan k. bioRxiv [Preprint]. 2021 Oct 13:2021.10.12.464114. doi: 10.1101/2021.10.12.464114. bioRxiv. 2021. Update in: PLoS Pathog. 2022 Feb 8;18(2):e1010248. doi: 10.1371/journal.ppat.1010248 PMID: 34671768 Free PMC article. Updated. Preprint.
Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV).
Khan K, Lustig G, Bernstein M, Archary D, Cele S, Karim F, Smith M, Ganga Y, Jule Z, Reedoy K, Miya Y, Mthabela N, Magula NP, Lessells R, de Oliveira T, Gosnell BI, Abdool Karim S, Garrett N, Hanekom W, Bekker LG, Gray G, Blackburn JM, Moosa MS, Sigal A; COMMIT-KZN Team. Khan K, et al. Clin Infect Dis. 2022 Aug 24;75(1):e857-e864. doi: 10.1093/cid/ciab1008. Clin Infect Dis. 2022. PMID: 34893824 Free PMC article.
SARS-CoV-2 evolved during advanced HIV disease immunosuppression has Beta-like escape of vaccine and Delta infection elicited immunity.
Cele S, Karim F, Lustig G, San JE, Hermanus T, Tegally H, Snyman J, Moyo-Gwete T, Wilkinson E, Bernstein M, Khan K, Hwa SH, Tilles SW, Singh L, Giandhari J, Mthabela N, Mazibuko M, Ganga Y, Gosnell BI, Karim SA, Hanekom W, Van Voorhis WC, Ndung'u T; COMMIT-KZN Team; Lessells RJ, Moore PL, Moosa MS, de Oliveira T, Sigal A. Cele S, et al. Among authors: khan k. medRxiv [Preprint]. 2021 Dec 7:2021.09.14.21263564. doi: 10.1101/2021.09.14.21263564. medRxiv. 2021. Update in: Cell Host Microbe. 2022 Feb 9;30(2):154-162.e5. doi: 10.1016/j.chom.2022.01.005 PMID: 34909798 Free PMC article. Updated. Preprint.
Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant.
Khan K, Karim F, Cele S, San JE, Lustig G, Tegally H, Rosenberg Y, Bernstein M, Ganga Y, Jule Z, Reedoy K, Ngcobo N, Mazibuko M, Mthabela N, Mhlane Z, Mbatha N, Miya Y, Giandhari J, Ramphal Y, Naidoo T, Manickchund N, Magula N, Abdool Karim SS, Gray G, Hanekom W, von Gottberg A; COMMIT-KZN Team; Milo R, Gosnell BI, Lessells RJ, Moore PL, de Oliveira T, Moosa MS, Sigal A. Khan K, et al. medRxiv [Preprint]. 2022 Jan 28:2021.12.27.21268439. doi: 10.1101/2021.12.27.21268439. medRxiv. 2022. Update in: Nature. 2022 Feb;602(7898):654-656. doi: 10.1038/s41586-021-04387-1 Update in: Nature. 2022 Jul;607(7918):356-359. doi: 10.1038/s41586-022-04830-x PMID: 34981076 Free PMC article. Updated. Preprint.
4,551 results