Yang C - Search Results

1

Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy.

Zhang J, Tang P, Zou L, Zhang J, Chen J, Yang C, He G, Liu B, Liu J, Chiang CM, Wang G, Ye T, Ouyang L. Zhang J, et al. Among authors: yang c. J Med Chem. 2021 Dec 23;64(24):18025-18053. doi: 10.1021/acs.jmedchem.1c01382. Epub 2021 Dec 15. J Med Chem. 2021. PMID: 34908415 Free PMC article.

2

Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy.

Yang C, Zhang J, Liao M, Yang Y, Wang Y, Yuan Y, Ouyang L. Yang C, et al. Among authors: yang y. Drug Discov Today. 2021 Mar;26(3):817-825. doi: 10.1016/j.drudis.2020.12.006. Epub 2020 Dec 11. Drug Discov Today. 2021. PMID: 33316375 Review.

3

Identification and optimization of 3-bromo-N'-(4-hydroxybenzylidene)-4-methylbenzohydrazide derivatives as mTOR inhibitors that induce autophagic cell death and apoptosis in triple-negative breast cancer.

Xu T, Zhang J, Yang C, Pluta R, Wang G, Ye T, Ouyang L. Xu T, et al. Among authors: yang c. Eur J Med Chem. 2021 Jul 5;219:113424. doi: 10.1016/j.ejmech.2021.113424. Epub 2021 Apr 3. Eur J Med Chem. 2021. PMID: 33862514

4

Discovery, Synthesis, and Evaluation of Highly Selective Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) Inhibitor for the Potential Treatment of Metastatic Triple-Negative Breast Cancer.

Li Y, Yang G, Zhang J, Tang P, Yang C, Wang G, Chen J, Liu J, Zhang L, Ouyang L. Li Y, et al. Among authors: yang c, yang g. J Med Chem. 2021 Aug 26;64(16):12022-12048. doi: 10.1021/acs.jmedchem.1c00678. Epub 2021 Aug 5. J Med Chem. 2021. PMID: 34351741

5

Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery.

Li Y, Yang G, Yang C, Tang P, Chen J, Zhang J, Liu J, Ouyang L. Li Y, et al. Among authors: yang c, yang g. J Med Chem. 2021 Aug 26;64(16):11798-11815. doi: 10.1021/acs.jmedchem.1c00579. Epub 2021 Aug 11. J Med Chem. 2021. PMID: 34378389

6

MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction.

Zhang L, Zhang L, Guo Y, Xiao M, Feng L, Yang C, Wang G, Ouyang L. Zhang L, et al. Among authors: yang c. Acta Pharm Sin B. 2021 Oct;11(10):3092-3104. doi: 10.1016/j.apsb.2021.05.032. Epub 2021 Jun 7. Acta Pharm Sin B. 2021. PMID: 34729303 Free PMC article.

7

Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models.

Liao M, Xie Q, Zhao Y, Yang C, Lin C, Wang G, Liu B, Zhu L. Liao M, et al. Among authors: yang c. Pharmacol Res. 2022 Feb;176:106077. doi: 10.1016/j.phrs.2022.106077. Epub 2022 Jan 10. Pharmacol Res. 2022. PMID: 35026404

8

Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development.

Chen J, Tang P, Wang Y, Wang J, Yang C, Li Y, Yang G, Wu F, Zhang J, Ouyang L. Chen J, et al. Among authors: yang c, yang g. J Med Chem. 2022 Apr 14;65(7):5184-5211. doi: 10.1021/acs.jmedchem.1c01835. Epub 2022 Mar 24. J Med Chem. 2022. PMID: 35324195

9

Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy.

Zhang J, Yang C, Tang P, Chen J, Zhang D, Li Y, Yang G, Liu Y, Zhang Y, Wang Y, Liu J, Ouyang L. Zhang J, et al. Among authors: yang c, yang g. J Med Chem. 2022 May 12;65(9):6803-6825. doi: 10.1021/acs.jmedchem.2c00135. Epub 2022 Apr 20. J Med Chem. 2022. PMID: 35442700

10

Discovery, Synthesis, and Evaluation of Novel Dual Inhibitors of a Vascular Endothelial Growth Factor Receptor and Poly(ADP-Ribose) Polymerase for BRCA Wild-Type Breast Cancer Therapy.

Li Y, Liu Y, Zhang D, Chen J, Yang G, Tang P, Yang C, Liu J, Zhang J, Ouyang L. Li Y, et al. Among authors: yang c, yang g. J Med Chem. 2023 Sep 14;66(17):12069-12100. doi: 10.1021/acs.jmedchem.3c00640. Epub 2023 Aug 24. J Med Chem. 2023. PMID: 37616488

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