Zunke F - Search Results

1

Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo.

Fredriksen K, Aivazidis S, Sharma K, Burbidge KJ, Pitcairn C, Zunke F, Gelyana E, Mazzulli JR. Fredriksen K, et al. Among authors: zunke f. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2108489118. doi: 10.1073/pnas.2108489118. Proc Natl Acad Sci U S A. 2021. PMID: 34893541 Free PMC article.

2

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.

Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J. Rothaug M, et al. Among authors: zunke f. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8. doi: 10.1073/pnas.1405700111. Epub 2014 Oct 14. Proc Natl Acad Sci U S A. 2014. PMID: 25316793 Free PMC article.

3

α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.

Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D. Mazzulli JR, et al. Among authors: zunke f. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1931-6. doi: 10.1073/pnas.1520335113. Epub 2016 Feb 2. Proc Natl Acad Sci U S A. 2016. PMID: 26839413 Free PMC article.

4

Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2.

Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M. Zunke F, et al. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3791-6. doi: 10.1073/pnas.1514005113. Epub 2016 Mar 21. Proc Natl Acad Sci U S A. 2016. PMID: 27001828 Free PMC article.

5

Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.

Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D. Mazzulli JR, et al. Among authors: zunke f. J Neurosci. 2016 Jul 20;36(29):7693-706. doi: 10.1523/JNEUROSCI.0628-16.2016. J Neurosci. 2016. PMID: 27445146 Free PMC article.

6

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.

Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR. Zunke F, et al. Neuron. 2018 Jan 3;97(1):92-107.e10. doi: 10.1016/j.neuron.2017.12.012. Epub 2017 Dec 28. Neuron. 2018. PMID: 29290548 Free PMC article.

7

Modeling neuronopathic storage diseases with patient-derived culture systems.

Zunke F, Mazzulli JR. Zunke F, et al. Neurobiol Dis. 2019 Jul;127:147-162. doi: 10.1016/j.nbd.2019.01.018. Epub 2019 Feb 19. Neurobiol Dis. 2019. PMID: 30790616 Free PMC article. Review.

8

Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.

Cuddy LK, Wani WY, Morella ML, Pitcairn C, Tsutsumi K, Fredriksen K, Justman CJ, Grammatopoulos TN, Belur NR, Zunke F, Subramanian A, Affaneh A, Lansbury PT Jr, Mazzulli JR. Cuddy LK, et al. Among authors: zunke f. Neuron. 2019 Dec 4;104(5):869-884.e11. doi: 10.1016/j.neuron.2019.09.001. Epub 2019 Oct 21. Neuron. 2019. PMID: 31648898 Free PMC article.

9

Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking.

Stojkovska I, Wani WY, Zunke F, Belur NR, Pavlenko EA, Mwenda N, Sharma K, Francelle L, Mazzulli JR. Stojkovska I, et al. Among authors: zunke f. Neuron. 2022 Feb 2;110(3):436-451.e11. doi: 10.1016/j.neuron.2021.10.032. Epub 2021 Nov 17. Neuron. 2022. PMID: 34793693 Free PMC article.

10

The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches.

Drobny A, Prieto Huarcaya S, Dobert J, Kluge A, Bunk J, Schlothauer T, Zunke F. Drobny A, et al. Among authors: zunke f. Biochim Biophys Acta Mol Cell Res. 2022 Jul;1869(7):119243. doi: 10.1016/j.bbamcr.2022.119243. Epub 2022 Feb 23. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 35217144 Free article. Review.

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