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Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.
Sokratian A, Zhou Y, Tatli M, Burbidge KJ, Xu E, Viverette E, Donzelli S, Duda AM, Yuan Y, Li H, Strader S, Patel N, Shiell L, Malankhanova T, Chen O, Mazzulli JR, Perera L, Stahlberg H, Borgnia M, Bartesaghi A, Lashuel HA, West AB. Sokratian A, et al. Among authors: burbidge kj. Sci Adv. 2024 Nov;10(44):eadq3539. doi: 10.1126/sciadv.adq3539. Epub 2024 Nov 1. Sci Adv. 2024. PMID: 39485845 Free article.
LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons.
Burbidge K, Rademacher DJ, Mattick J, Zack S, Grillini A, Bousset L, Kwon O, Kubicki K, Simon A, Melki R, Campbell EM. Burbidge K, et al. Autophagy. 2022 May;18(5):1020-1048. doi: 10.1080/15548627.2021.1967615. Epub 2021 Oct 6. Autophagy. 2022. PMID: 34612142 Free PMC article.