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Structure of parkin reveals mechanisms for ubiquitin ligase activation.
Trempe JF, Sauvé V, Grenier K, Seirafi M, Tang MY, Ménade M, Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K. Trempe JF, et al. Science. 2013 Jun 21;340(6139):1451-5. doi: 10.1126/science.1237908. Epub 2013 May 9. Science. 2013. PMID: 23661642
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe JF, Saeki Y, Tanaka K, Matsuda N. Koyano F, et al. Among authors: trempe jf. Nature. 2014 Jun 5;510(7503):162-6. doi: 10.1038/nature13392. Epub 2014 Jun 4. Nature. 2014. PMID: 24784582
A Ubl/ubiquitin switch in the activation of Parkin.
Sauvé V, Lilov A, Seirafi M, Vranas M, Rasool S, Kozlov G, Sprules T, Wang J, Trempe JF, Gehring K. Sauvé V, et al. Among authors: trempe jf. EMBO J. 2015 Oct 14;34(20):2492-505. doi: 10.15252/embj.201592237. Epub 2015 Aug 7. EMBO J. 2015. PMID: 26254305 Free PMC article.
PINK1 autophosphorylation is required for ubiquitin recognition.
Rasool S, Soya N, Truong L, Croteau N, Lukacs GL, Trempe JF. Rasool S, et al. Among authors: trempe jf. EMBO Rep. 2018 Apr;19(4):e44981. doi: 10.15252/embr.201744981. Epub 2018 Feb 23. EMBO Rep. 2018. PMID: 29475881 Free PMC article.
84 results