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Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment.
Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE. Matthias J, et al. Among authors: chao yy. Sci Transl Med. 2019 Feb 20;11(480):eaau0683. doi: 10.1126/scitranslmed.aau0683. Sci Transl Med. 2019. PMID: 30787167
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. Lückel C, et al. Among authors: chao yy. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z. Nat Commun. 2019. PMID: 31844089 Free PMC article.
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.
Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE. Matthias J, et al. Among authors: chao yy. J Clin Invest. 2020 Sep 1;130(9):4587-4600. doi: 10.1172/JCI137786. J Clin Invest. 2020. PMID: 32484796 Free PMC article.
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.
Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE. Chao YY, et al. Nat Immunol. 2023 Feb;24(2):295-308. doi: 10.1038/s41590-022-01386-w. Epub 2023 Jan 5. Nat Immunol. 2023. PMID: 36604548 Free PMC article.
128 results