Struglics A - Search Results

1

Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS-5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip.

van der Aar E, Deckx H, Dupont S, Fieuw A, Delage S, Larsson S, Struglics A, Lohmander LS, Lalande A, Leroux E, Amantini D, Passier P. van der Aar E, et al. Among authors: struglics a. Clin Pharmacol Drug Dev. 2022 Jan;11(1):112-122. doi: 10.1002/cpdd.1042. Epub 2021 Dec 2. Clin Pharmacol Drug Dev. 2022. PMID: 34859612 Free PMC article.

2

Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.

Struglics A, Larsson S, Pratta MA, Kumar S, Lark MW, Lohmander LS. Struglics A, et al. Osteoarthritis Cartilage. 2006 Feb;14(2):101-13. doi: 10.1016/j.joca.2005.07.018. Epub 2005 Sep 26. Osteoarthritis Cartilage. 2006. PMID: 16188468 Free article.

3

Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis.

Lohmander LS, Brandt KD, Mazzuca SA, Katz BP, Larsson S, Struglics A, Lane KA. Lohmander LS, et al. Among authors: struglics a. Arthritis Rheum. 2005 Oct;52(10):3160-7. doi: 10.1002/art.21345. Arthritis Rheum. 2005. PMID: 16200596 Free article. Clinical Trial.

4

Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments.

Pratta MA, Su JL, Leesnitzer MA, Struglics A, Larsson S, Lohmander LS, Kumar S. Pratta MA, et al. Among authors: struglics a. Osteoarthritis Cartilage. 2006 Jul;14(7):702-13. doi: 10.1016/j.joca.2006.01.012. Epub 2006 Mar 20. Osteoarthritis Cartilage. 2006. PMID: 16549371 Free article.

5

Estimation of the identity of proteolytic aggrecan fragments using PAGE migration and Western immunoblot.

Struglics A, Larsson S, Lohmander LS. Struglics A, et al. Osteoarthritis Cartilage. 2006 Sep;14(9):898-905. doi: 10.1016/j.joca.2006.02.016. Epub 2006 Apr 24. Osteoarthritis Cartilage. 2006. PMID: 16635583 Free article.

6

Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases.

Struglics A, Larsson S, Hansson M, Lohmander LS. Struglics A, et al. Osteoarthritis Cartilage. 2009 Apr;17(4):497-506. doi: 10.1016/j.joca.2008.09.017. Epub 2008 Oct 17. Osteoarthritis Cartilage. 2009. PMID: 19095471 Free article.

7

Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study.

Larsson S, Lohmander LS, Struglics A. Larsson S, et al. Among authors: struglics a. Arthritis Res Ther. 2009;11(3):R92. doi: 10.1186/ar2735. Epub 2009 Jun 22. Arthritis Res Ther. 2009. PMID: 19545413 Free PMC article.

8

A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid.

Struglics A, Larsson S. Struglics A, et al. Matrix Biol. 2010 Jan;29(1):74-83. doi: 10.1016/j.matbio.2009.08.006. Epub 2009 Sep 8. Matrix Biol. 2010. PMID: 19744558

9

Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.

Larsson S, Englund M, Struglics A, Lohmander LS. Larsson S, et al. Among authors: struglics a. Arthritis Res Ther. 2010;12(6):R230. doi: 10.1186/ar3217. Epub 2010 Dec 31. Arthritis Res Ther. 2010. PMID: 21194461 Free PMC article.

10

Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and chondroitin sulfate domains.

Struglics A, Hansson M, Lohmander LS. Struglics A, et al. Osteoarthritis Cartilage. 2011 Aug;19(8):1047-57. doi: 10.1016/j.joca.2011.05.006. Epub 2011 May 25. Osteoarthritis Cartilage. 2011. PMID: 21664283 Free article.

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