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Identification and characterization of an atypical Gαs-biased β2AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis.
Kim D, Tokmakova A, Lujan LK, Strzelinski HR, Kim N, Najari Beidokhti M, Giulianotti MA, Mafi A, Woo JA, An SS, Goddard WA 3rd, Liggett SB. Kim D, et al. Among authors: liggett sb. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2026668118. doi: 10.1073/pnas.2026668118. Proc Natl Acad Sci U S A. 2021. PMID: 34857633 Free PMC article.
Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle.
Wang WC, Pauer SH, Smith DC, Dixon MA, Disimile DJ, Panebra A, An SS, Camoretti-Mercado B, Liggett SB. Wang WC, et al. Among authors: liggett sb. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L775-80. doi: 10.1152/ajplung.00209.2014. Epub 2014 Sep 26. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 25260754 Free PMC article.
An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.
An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA Jr, Solway J, Liggett SB. An SS, et al. Among authors: liggett sb. J Allergy Clin Immunol. 2016 Jul;138(1):294-297.e4. doi: 10.1016/j.jaci.2015.12.1315. Epub 2016 Feb 28. J Allergy Clin Immunol. 2016. PMID: 26936804 Free PMC article. No abstract available.
283 results