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Identification and characterization of an atypical Gαs-biased β2AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis.
Kim D, Tokmakova A, Lujan LK, Strzelinski HR, Kim N, Najari Beidokhti M, Giulianotti MA, Mafi A, Woo JA, An SS, Goddard WA 3rd, Liggett SB. Kim D, et al. Among authors: giulianotti ma. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2026668118. doi: 10.1073/pnas.2026668118. Proc Natl Acad Sci U S A. 2021. PMID: 34857633 Free PMC article.
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.
Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C. Doering SR, et al. Among authors: giulianotti ma. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. J Med Chem. 2021. PMID: 33886285 Free PMC article.
Integrating computational and mixture-based screening of combinatorial libraries.
Yongye AB, Pinilla C, Medina-Franco JL, Giulianotti MA, Dooley CT, Appel JR, Nefzi A, Scior T, Houghten RA, Martínez-Mayorga K. Yongye AB, et al. Among authors: giulianotti ma. J Mol Model. 2011 Jun;17(6):1473-82. doi: 10.1007/s00894-010-0850-1. Epub 2010 Sep 21. J Mol Model. 2011. PMID: 20853183
Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries.
Tran T, Chiem K, Jani S, Arivett BA, Lin DL, Lad R, Jimenez V, Farone MB, Debevec G, Santos R, Giulianotti M, Pinilla C, Tolmasky ME. Tran T, et al. Int J Antimicrob Agents. 2018 May;51(5):752-761. doi: 10.1016/j.ijantimicag.2018.01.019. Epub 2018 Feb 2. Int J Antimicrob Agents. 2018. PMID: 29410367 Free PMC article.
84 results