Yu K - Search Results

1

LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo.

Liu Y, Lai M, Li S, Wang Y, Feng F, Zhang T, Tong L, Zhang M, Chen H, Chen Y, Song P, Li Y, Bai G, Ning Y, Tang H, Fang Y, Chen Y, Lu X, Geng M, Ding K, Yu K, Xie H, Ding J. Liu Y, et al. Among authors: yu k. Cancer Sci. 2022 Feb;113(2):709-720. doi: 10.1111/cas.15229. Epub 2021 Dec 16. Cancer Sci. 2022. PMID: 34855271 Free PMC article.

2

A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers.

Meng L, Shu M, Chen Y, Yang D, He Q, Zhao H, Feng Z, Liang C, Yu K. Meng L, et al. Among authors: yu k. Cancer Biol Ther. 2014 Jun 1;15(6):721-34. doi: 10.4161/cbt.28409. Epub 2014 Mar 11. Cancer Biol Ther. 2014. PMID: 24618813 Free PMC article.

3

A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial-Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer.

Zhang Q, Zhang Y, Chen Y, Qian J, Zhang X, Yu K. Zhang Q, et al. Among authors: yu k. Clin Cancer Res. 2019 Jun 15;25(12):3630-3642. doi: 10.1158/1078-0432.CCR-18-2548. Epub 2019 Feb 22. Clin Cancer Res. 2019. PMID: 30796032

4

Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody-Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function.

Jin R, Liu L, Xing Y, Meng T, Ma L, Pei J, Cong Y, Zhang X, Ren Z, Wang X, Shen J, Yu K. Jin R, et al. Among authors: yu k. Mol Cancer Ther. 2020 Nov;19(11):2340-2352. doi: 10.1158/1535-7163.MCT-20-0076. Epub 2020 Sep 17. Mol Cancer Ther. 2020. PMID: 32943546

5

Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy.

Liu C, Zhou F, Yan Z, Shen L, Zhang X, He F, Wang H, Lu X, Yu K, Zhao Y, Zhu D. Liu C, et al. Among authors: yu k. Br J Pharmacol. 2021 Jul;178(13):2651-2670. doi: 10.1111/bph.15457. Epub 2021 May 4. Br J Pharmacol. 2021. PMID: 33768523 Free article.

6

Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

Yu K, Shi C, Toral-Barza L, Lucas J, Shor B, Kim JE, Zhang WG, Mahoney R, Gaydos C, Tardio L, Kim SK, Conant R, Curran K, Kaplan J, Verheijen J, Ayral-Kaloustian S, Mansour TS, Abraham RT, Zask A, Gibbons JJ. Yu K, et al. Cancer Res. 2010 Jan 15;70(2):621-31. doi: 10.1158/0008-5472.CAN-09-2340. Epub 2010 Jan 12. Cancer Res. 2010. PMID: 20068177

7

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer.

Qian J, Chen Y, Meng T, Ma L, Meng L, Wang X, Yu T, Zask A, Shen J, Yu K. Qian J, et al. Among authors: yu t, yu k. Oncotarget. 2016 Oct 11;7(41):67071-67086. doi: 10.18632/oncotarget.11490. Oncotarget. 2016. PMID: 27563814 Free PMC article.

8

Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.

Li QR, Zhao H, Zhang XS, Lang H, Yu K. Li QR, et al. Among authors: yu k. Acta Pharmacol Sin. 2019 Feb;40(2):257-267. doi: 10.1038/s41401-018-0019-5. Epub 2018 May 18. Acta Pharmacol Sin. 2019. PMID: 29777201 Free PMC article.

9

Non-immunogenic, low-toxicity and effective glioma targeting MTI-31 liposomes.

Wang X, Meng N, Wang S, Zhang Y, Lu L, Wang R, Ruan H, Jiang K, Wang H, Ran D, Zhan C, Yu K, Burgess DJ, Lu W. Wang X, et al. Among authors: yu k. J Control Release. 2019 Dec 28;316:381-392. doi: 10.1016/j.jconrel.2019.11.005. Epub 2019 Nov 12. J Control Release. 2019. PMID: 31730912

10

BCL9 regulates CD226 and CD96 checkpoints in CD8⁺ T cells to improve PD-1 response in cancer.

Feng M, Wu Z, Zhou Y, Wei Z, Tian E, Mei S, Zhu Y, Liu C, He F, Li H, Xie C, Jin J, Dong J, Yang D, Yu K, Qian J, Lambrechts D, Wang MW, Zhu D. Feng M, et al. Among authors: yu k. Signal Transduct Target Ther. 2021 Aug 20;6(1):313. doi: 10.1038/s41392-021-00730-0. Signal Transduct Target Ther. 2021. PMID: 34417435 Free PMC article.

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