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Page 1
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T. Pluvinage JV, et al. Among authors: bertozzi cr. Sci Transl Med. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851695 Free PMC article.
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T. Pluvinage JV, et al. Among authors: bertozzi cr. Nature. 2019 Apr;568(7751):187-192. doi: 10.1038/s41586-019-1088-4. Epub 2019 Apr 3. Nature. 2019. PMID: 30944478 Free PMC article.
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.
Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T. Marschallinger J, et al. Among authors: bertozzi cr. Nat Neurosci. 2020 Feb;23(2):194-208. doi: 10.1038/s41593-019-0566-1. Epub 2020 Jan 20. Nat Neurosci. 2020. PMID: 31959936 Free PMC article.
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.
Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T. Marschallinger J, et al. Among authors: bertozzi cr. Nat Neurosci. 2020 Feb;23(2):294. doi: 10.1038/s41593-020-0595-9. Nat Neurosci. 2020. PMID: 32005940
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.
Shao Z, Flynn RA, Crowe JL, Zhu Y, Liang J, Jiang W, Aryan F, Aoude P, Bertozzi CR, Estes VM, Lee BJ, Bhagat G, Zha S, Calo E. Shao Z, et al. Among authors: bertozzi cr. Nature. 2020 Mar;579(7798):291-296. doi: 10.1038/s41586-020-2041-2. Epub 2020 Feb 26. Nature. 2020. PMID: 32103174 Free PMC article.
Optimal Dissociation Methods Differ for N- and O-Glycopeptides.
Riley NM, Malaker SA, Driessen MD, Bertozzi CR. Riley NM, et al. Among authors: bertozzi cr. J Proteome Res. 2020 Aug 7;19(8):3286-3301. doi: 10.1021/acs.jproteome.0c00218. Epub 2020 Jun 28. J Proteome Res. 2020. PMID: 32500713 Free PMC article.
Physiological blood-brain transport is impaired with age by a shift in transcytosis.
Yang AC, Stevens MY, Chen MB, Lee DP, Stähli D, Gate D, Contrepois K, Chen W, Iram T, Zhang L, Vest RT, Chaney A, Lehallier B, Olsson N, du Bois H, Hsieh R, Cropper HC, Berdnik D, Li L, Wang EY, Traber GM, Bertozzi CR, Luo J, Snyder MP, Elias JE, Quake SR, James ML, Wyss-Coray T. Yang AC, et al. Among authors: bertozzi cr. Nature. 2020 Jul;583(7816):425-430. doi: 10.1038/s41586-020-2453-z. Epub 2020 Jul 1. Nature. 2020. PMID: 32612231 Free PMC article.
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.
Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T. Marschallinger J, et al. Among authors: bertozzi cr. Nat Neurosci. 2020 Oct;23(10):1308. doi: 10.1038/s41593-020-0682-y. Nat Neurosci. 2020. PMID: 32719564
555 results