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Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with advanced solid tumors.
Naing A, Eder JP, Piha-Paul SA, Gimmi C, Hussey E, Zhang S, Hildebrand V, Hosagrahara V, Habermehl C, Moisan J, Papadopoulos KP. Naing A, et al. Among authors: gimmi c. J Immunother Cancer. 2020 Aug;8(2):e000870. doi: 10.1136/jitc-2020-000870. J Immunother Cancer. 2020. PMID: 32843490 Free PMC article. Clinical Trial.
Virosomes as new carrier system for cancer vaccines.
Schwaninger R, Waelti E, Zajac P, Wetterwald A, Mueller D, Gimmi CD. Schwaninger R, et al. Among authors: gimmi cd. Cancer Immunol Immunother. 2004 Nov;53(11):1005-17. doi: 10.1007/s00262-004-0545-5. Epub 2004 Jun 5. Cancer Immunol Immunother. 2004. PMID: 15185010 Free PMC article.
The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker.
Lee L, Niu H, Rueger R, Igawa Y, Deutsch J, Ishii N, Mu S, Sakamoto Y, Busse-Reid R, Gimmi C, Goelzer P, De Schepper S, Yoshimura Y, Barrett J, Ishikawa Y, Weissgerber G, Peck R. Lee L, et al. Among authors: gimmi c. Clin Cancer Res. 2009 Dec 1;15(23):7368-74. doi: 10.1158/1078-0432.CCR-09-1696. Epub 2009 Nov 24. Clin Cancer Res. 2009. PMID: 19934286 Clinical Trial.
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