Abbott BM - Search Results

1

Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase.

Christoff RM, Soares da Costa TP, Bayat S, Holien JK, Perugini MA, Abbott BM. Christoff RM, et al. Among authors: abbott bm. Bioorg Med Chem. 2021 Dec 15;52:116518. doi: 10.1016/j.bmc.2021.116518. Epub 2021 Nov 12. Bioorg Med Chem. 2021. PMID: 34826680

2

PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues.

Abbott BM, Thompson PE. Abbott BM, et al. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51. doi: 10.1016/j.bmcl.2004.03.043. Bioorg Med Chem Lett. 2004. PMID: 15125945

3

Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity.

Abbott BM, Thompson PE. Abbott BM, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):969-73. doi: 10.1016/j.bmcl.2005.10.092. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16290931

4

Potent inhibitors of phosphatidylinositol 3 (PI3) kinase that have antiproliferative activity only when delivered as prodrug forms.

O'Brien NJ, Amran S, Medan J, Cleary B, Deady LW, Jennings IG, Thompson PE, Abbott BM. O'Brien NJ, et al. Among authors: abbott bm. ChemMedChem. 2013 Jun;8(6):914-8. doi: 10.1002/cmdc.201200583. Epub 2013 Apr 8. ChemMedChem. 2013. PMID: 23568455

5

Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors.

O'Brien NJ, Brzozowski M, Wilson DJ, Deady LW, Abbott BM. O'Brien NJ, et al. Among authors: abbott bm. Bioorg Med Chem. 2014 Jul 15;22(14):3781-90. doi: 10.1016/j.bmc.2014.04.037. Epub 2014 May 9. Bioorg Med Chem. 2014. PMID: 24856302

6

Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors.

O'Brien NJ, Brzozowski M, Buskes MJ, Deady LW, Abbott BM. O'Brien NJ, et al. Among authors: abbott bm. Bioorg Med Chem. 2014 Aug 1;22(15):3879-86. doi: 10.1016/j.bmc.2014.06.018. Epub 2014 Jun 18. Bioorg Med Chem. 2014. PMID: 25012568

7

Quaternary Structure Analyses of an Essential Oligomeric Enzyme.

Soares da Costa TP, Christensen JB, Desbois S, Gordon SE, Gupta R, Hogan CJ, Nelson TG, Downton MT, Gardhi CK, Abbott BM, Wagner J, Panjikar S, Perugini MA. Soares da Costa TP, et al. Among authors: abbott bm. Methods Enzymol. 2015;562:205-23. doi: 10.1016/bs.mie.2015.06.020. Epub 2015 Aug 13. Methods Enzymol. 2015. PMID: 26412653 Review.

8

Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis.

Browne EC, Parakh S, Duncan LF, Langford SJ, Atkin JD, Abbott BM. Browne EC, et al. Among authors: abbott bm. Bioorg Med Chem. 2016 Apr 1;24(7):1520-7. doi: 10.1016/j.bmc.2016.02.022. Epub 2016 Feb 18. Bioorg Med Chem. 2016. PMID: 26935939

9

Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation.

Buskes MJ, Harvey KL, Richards BJ, Kalhor R, Christoff RM, Gardhi CK, Littler DR, Cope ED, Prinz B, Weiss GE, O'Brien NJ, Crabb BS, Deady LW, Gilson PR, Abbott BM. Buskes MJ, et al. Among authors: abbott bm. Org Biomol Chem. 2016 May 18;14(20):4617-39. doi: 10.1039/c5ob02517f. Org Biomol Chem. 2016. PMID: 27105169

10

Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum.

Buskes MJ, Harvey KL, Prinz B, Crabb BS, Gilson PR, Wilson DJD, Abbott BM. Buskes MJ, et al. Among authors: abbott bm. Bioorg Med Chem. 2016 Jun 1;24(11):2389-2396. doi: 10.1016/j.bmc.2016.03.048. Epub 2016 Mar 28. Bioorg Med Chem. 2016. PMID: 27112453

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