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Dysregulation of the mevalonate pathway promotes transformation.
Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I, Penn LZ. Clendening JW, et al. Among authors: trentin ga. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15051-6. doi: 10.1073/pnas.0910258107. Epub 2010 Aug 9. Proc Natl Acad Sci U S A. 2010. PMID: 20696928 Free PMC article.
CUL7 is a novel antiapoptotic oncogene.
Kim SS, Shago M, Kaustov L, Boutros PC, Clendening JW, Sheng Y, Trentin GA, Barsyte-Lovejoy D, Mao DY, Kay R, Jurisica I, Arrowsmith CH, Penn LZ. Kim SS, et al. Among authors: trentin ga. Cancer Res. 2007 Oct 15;67(20):9616-22. doi: 10.1158/0008-5472.CAN-07-0644. Cancer Res. 2007. PMID: 17942889