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Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models.
Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Singh S, et al. Among authors: singh r. Sci Adv. 2021 Nov 19;7(47):eabj5405. doi: 10.1126/sciadv.abj5405. Epub 2021 Nov 17. Sci Adv. 2021. PMID: 34788094 Free PMC article.
Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma.
Jacob AG, O'Brien D, Singh RK, Comiskey DF Jr, Littleton RM, Mohammad F, Gladman JT, Widmann MC, Jeyaraj SC, Bolinger C, Anderson JR, Barkauskas DA, Boris-Lawrie K, Chandler DS. Jacob AG, et al. Among authors: singh rk. Neoplasia. 2013 Sep;15(9):1049-63. doi: 10.1593/neo.13286. Neoplasia. 2013. PMID: 24027430 Free PMC article.
Pre-mRNA splicing in disease and therapeutics.
Singh RK, Cooper TA. Singh RK, et al. Trends Mol Med. 2012 Aug;18(8):472-82. doi: 10.1016/j.molmed.2012.06.006. Epub 2012 Jul 18. Trends Mol Med. 2012. PMID: 22819011 Free PMC article. Review.
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