Yang H - Search Results

1

Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy.

Zhang Z, Guo Z, Xu X, Cao D, Yang H, Li Y, Shi Q, Du Z, Guo X, Wang X, Chen D, Zhang Y, Chen L, Zhou K, Li J, Geng M, Huang X, Xiong B. Zhang Z, et al. Among authors: yang h. J Med Chem. 2021 Nov 25;64(22):16650-16674. doi: 10.1021/acs.jmedchem.1c01308. Epub 2021 Nov 15. J Med Chem. 2021. PMID: 34781683

2

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Sleebs BE, Kersten WJ, Kulasegaram S, Nikolakopoulos G, Hatzis E, Moss RM, Parisot JP, Yang H, Czabotar PE, Fairlie WD, Lee EF, Adams JM, Chen L, van Delft MF, Lowes KN, Wei A, Huang DC, Colman PM, Street IP, Baell JB, Watson K, Lessene G. Sleebs BE, et al. Among authors: yang h. J Med Chem. 2013 Jul 11;56(13):5514-40. doi: 10.1021/jm400556w. Epub 2013 Jun 26. J Med Chem. 2013. PMID: 23767404

3

CTC clusters induced by heparanase enhance breast cancer metastasis.

Wei RR, Sun DN, Yang H, Yan J, Zhang X, Zheng XL, Fu XH, Geng MY, Huang X, Ding J. Wei RR, et al. Among authors: yang h. Acta Pharmacol Sin. 2018 Aug;39(8):1326-1337. doi: 10.1038/aps.2017.189. Epub 2018 Feb 8. Acta Pharmacol Sin. 2018. PMID: 29417941 Free PMC article.

4

Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs.

Geng K, Liu H, Song Z, Zhang C, Zhang M, Yang H, Cao J, Geng M, Shen A, Zhang A. Geng K, et al. Among authors: yang h. Eur J Med Chem. 2018 May 25;152:76-86. doi: 10.1016/j.ejmech.2018.04.019. Epub 2018 Apr 11. Eur J Med Chem. 2018. PMID: 29698859

5

Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.

Zhang X, Zheng X, Yang H, Yan J, Fu X, Wei R, Xu X, Zhang Z, Yu A, Zhou K, Ding J, Geng M, Huang X. Zhang X, et al. Among authors: yang h. Cancer Lett. 2018 Sep 1;431:150-160. doi: 10.1016/j.canlet.2018.05.034. Epub 2018 May 30. Cancer Lett. 2018. PMID: 29857126

6

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M, Ding J, Geng M. Huang X, et al. Among authors: yang h. Cell. 2018 Sep 20;175(1):186-199.e19. doi: 10.1016/j.cell.2018.08.058. Epub 2018 Sep 13. Cell. 2018. PMID: 30220457 Free article.

7

CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.

Fu XH, Zhang X, Yang H, Xu XW, Hu ZL, Yan J, Zheng XL, Wei RR, Zhang ZQ, Tang SR, Geng MY, Huang X. Fu XH, et al. Among authors: yang h. Acta Pharmacol Sin. 2019 May;40(5):677-688. doi: 10.1038/s41401-018-0108-5. Epub 2018 Sep 17. Acta Pharmacol Sin. 2019. PMID: 30224636 Free PMC article.

8

Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.

Guo Z, Zhang Z, Yang H, Cao D, Xu X, Zheng X, Chen D, Wang Q, Li Y, Li J, Du Z, Wang X, Chen L, Ding J, Shen J, Geng M, Huang X, Xiong B. Guo Z, et al. Among authors: yang h. J Med Chem. 2019 Jun 13;62(11):5414-5433. doi: 10.1021/acs.jmedchem.9b00297. Epub 2019 Jun 4. J Med Chem. 2019. PMID: 31117515

9

Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.

Liu R, Zhang Z, Yang H, Zhou K, Geng M, Zhou W, Zhang M, Huang X, Li Y. Liu R, et al. Among authors: yang h. Eur J Med Chem. 2019 Oct 15;180:171-190. doi: 10.1016/j.ejmech.2019.07.026. Epub 2019 Jul 9. Eur J Med Chem. 2019. PMID: 31306905

10

Corrigendum to "Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors" [Eur. J. Med. Chem. 180 (2019) 171e190].

Liu R, Zhang Z, Yang H, Zhou K, Geng M, Zhou W, Zhang M, Huang X, Li Y. Liu R, et al. Among authors: yang h. Eur J Med Chem. 2020 Jan 15;186:111899. doi: 10.1016/j.ejmech.2019.111899. Epub 2019 Nov 29. Eur J Med Chem. 2020. PMID: 31787358 No abstract available.

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