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Page 1
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.
Fiorillo B, Sepe V, Conflitti P, Roselli R, Biagioli M, Marchianò S, De Luca P, Baronissi G, Rapacciuolo P, Cassiano C, Catalanotti B, Zampella A, Limongelli V, Fiorucci S. Fiorillo B, et al. Among authors: rapacciuolo p. J Med Chem. 2021 Nov 25;64(22):16512-16529. doi: 10.1021/acs.jmedchem.1c01078. Epub 2021 Nov 12. J Med Chem. 2021. PMID: 34767347
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease.
Fiorucci S, Rapacciuolo P, Fiorillo B, Roselli R, Marchianò S, Di Giorgio C, Bordoni M, Bellini R, Cassiano C, Conflitti P, Catalanotti B, Limongelli V, Sepe V, Biagioli M, Zampella A. Fiorucci S, et al. Among authors: rapacciuolo p. Front Pharmacol. 2022 Apr 25;13:858137. doi: 10.3389/fphar.2022.858137. eCollection 2022. Front Pharmacol. 2022. PMID: 35559268 Free PMC article.
Design, Synthesis, and Pharmacological Evaluation of Dual FXR-LIFR Modulators for the Treatment of Liver Fibrosis.
Rapacciuolo P, Finamore C, Giorgio CD, Fiorillo B, Massa C, Urbani G, Marchianò S, Bordoni M, Cassiano C, Morretta E, Spinelli L, Lupia A, Moraca F, Biagioli M, Sepe V, Monti MC, Catalanotti B, Fiorucci S, Zampella A. Rapacciuolo P, et al. J Med Chem. 2024 Oct 24;67(20):18334-18355. doi: 10.1021/acs.jmedchem.4c01651. Epub 2024 Oct 9. J Med Chem. 2024. PMID: 39382988
BAR502/fibrate conjugates: synthesis, biological evaluation and metabolic profile.
Finamore C, De Marino S, Cassiano C, Napolitano G, Rapacciuolo P, Marchianò S, Biagioli M, Roselli R, Di Giorgio C, Festa C, Fiorucci S, Zampella A. Finamore C, et al. Among authors: rapacciuolo p. Front Chem. 2024 Jul 17;12:1425867. doi: 10.3389/fchem.2024.1425867. eCollection 2024. Front Chem. 2024. PMID: 39086986 Free PMC article.
Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis.
Di Giorgio C, Morretta E, Lupia A, Bellini R, Massa C, Urbani G, Bordoni M, Marchianò S, Lachi G, Rapacciuolo P, Finamore C, Sepe V, Chiara Monti M, Moraca F, Natalizi N, Graziosi L, Distrutti E, Biagioli M, Catalanotti B, Donini A, Zampella A, Fiorucci S. Di Giorgio C, et al. Among authors: rapacciuolo p. Biochem Pharmacol. 2024 May;223:116134. doi: 10.1016/j.bcp.2024.116134. Epub 2024 Mar 15. Biochem Pharmacol. 2024. PMID: 38494064 Free article.
Correction to "Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders".
Fiorillo B, Roselli R, Finamore C, Biagioli M, di Giorgio C, Bordoni M, Conflitti P, Marchianò S, Bellini R, Rapacciuolo P, Cassiano C, Limongelli V, Sepe V, Catalanotti B, Fiorucci S, Zampella A. Fiorillo B, et al. Among authors: rapacciuolo p. ACS Omega. 2023 Nov 16;8(47):45163. doi: 10.1021/acsomega.3c08464. eCollection 2023 Nov 28. ACS Omega. 2023. PMID: 38046314 Free PMC article.
The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer.
Di Giorgio C, Bellini R, Lupia A, Massa C, Urbani G, Bordoni M, Marchianò S, Rosselli R, De Gregorio R, Rapacciuolo P, Sepe V, Morretta E, Monti MC, Moraca F, Cari L, Ullah KRS, Natalizi N, Graziosi L, Distrutti E, Biagioli M, Catalanotti B, Donini A, Zampella A, Fiorucci S. Di Giorgio C, et al. Among authors: rapacciuolo p. Cell Oncol (Dordr). 2024 Apr;47(2):695-710. doi: 10.1007/s13402-023-00893-8. Epub 2023 Nov 9. Cell Oncol (Dordr). 2024. PMID: 37945798 Free PMC article.
Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma.
Di Giorgio C, Bellini R, Lupia A, Massa C, Bordoni M, Marchianò S, Rosselli R, Sepe V, Rapacciuolo P, Moraca F, Morretta E, Ricci P, Urbani G, Monti MC, Biagioli M, Distrutti E, Catalanotti B, Zampella A, Fiorucci S. Di Giorgio C, et al. Among authors: rapacciuolo p. Front Oncol. 2023 Mar 14;13:1140730. doi: 10.3389/fonc.2023.1140730. eCollection 2023. Front Oncol. 2023. PMID: 36998446 Free PMC article.
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