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Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia.
El Khawanky N, Hughes A, Yu W, Myburgh R, Matschulla T, Taromi S, Aumann K, Clarson J, Vinnakota JM, Shoumariyeh K, Miething C, Lopez AF, Brown MP, Duyster J, Hein L, Manz MG, Hughes TP, White DL, Yong ASM, Zeiser R. El Khawanky N, et al. Among authors: brown mp. Nat Commun. 2021 Nov 8;12(1):6436. doi: 10.1038/s41467-021-26683-0. Nat Commun. 2021. PMID: 34750374 Free PMC article.
Dasatinib alters the metastatic phenotype of B16-OVA melanoma in vivo.
Fraser CK, Lousberg EL, Guerin LR, Hughes TP, Brown MP, Diener KR, Hayball JD. Fraser CK, et al. Among authors: brown mp. Cancer Biol Ther. 2010 Oct 1;10(7):715-27. doi: 10.4161/cbt.10.7.12926. Epub 2010 Oct 1. Cancer Biol Ther. 2010. PMID: 20676039 Free article.
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma.
Gargett T, Ebert LM, Truong NTH, Kollis PM, Sedivakova K, Yu W, Yeo ECF, Wittwer NL, Gliddon BL, Tea MN, Ormsby R, Poonnoose S, Nowicki J, Vittorio O, Ziegler DS, Pitson SM, Brown MP. Gargett T, et al. Among authors: brown mp. J Immunother Cancer. 2022 Sep;10(9):e005187. doi: 10.1136/jitc-2022-005187. J Immunother Cancer. 2022. PMID: 36167468 Free PMC article.
Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid cancers.
Gargett T, Truong NTH, Gardam B, Yu W, Ebert LM, Johnson A, Yeo ECF, Wittwer NL, Tapia Rico G, Logan J, Sivaloganathan P, Collis M, Ruszkiewicz A, Brown MP. Gargett T, et al. Among authors: brown mp. J Immunother Cancer. 2024 May 15;12(5):e008659. doi: 10.1136/jitc-2023-008659. J Immunother Cancer. 2024. PMID: 38754916 Free PMC article. Clinical Trial.
325 results