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Page 1
GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions.
Brun S, Bestion E, Raymond E, Bassissi F, Jilkova ZM, Mezouar S, Rachid M, Novello M, Tracz J, Hamaï A, Lalmanach G, Vanderlynden L, Legouffe R, Stauber J, Schubert T, Plach MG, Courcambeck J, Drouot C, Jacquemot G, Serdjebi C, Roth G, Baudoin JP, Ansaldi C, Decaens T, Halfon P. Brun S, et al. Among authors: drouot c. Autophagy. 2022 Mar;18(3):678-694. doi: 10.1080/15548627.2021.1988357. Epub 2021 Nov 5. Autophagy. 2022. PMID: 34740311 Free PMC article.
TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition.
Schaller S, Paradis S, Ngoh GA, Assaly R, Buisson B, Drouot C, Ostuni MA, Lacapere JJ, Bassissi F, Bordet T, Berdeaux A, Jones SP, Morin D, Pruss RM. Schaller S, et al. Among authors: drouot c. J Pharmacol Exp Ther. 2010 Jun;333(3):696-706. doi: 10.1124/jpet.110.167486. Epub 2010 Mar 9. J Pharmacol Exp Ther. 2010. PMID: 20215409 Free article.
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
Bordet T, Buisson B, Michaud M, Drouot C, Galéa P, Delaage P, Akentieva NP, Evers AS, Covey DF, Ostuni MA, Lacapère JJ, Massaad C, Schumacher M, Steidl EM, Maux D, Delaage M, Henderson CE, Pruss RM. Bordet T, et al. Among authors: drouot c. J Pharmacol Exp Ther. 2007 Aug;322(2):709-20. doi: 10.1124/jpet.107.123000. Epub 2007 May 11. J Pharmacol Exp Ther. 2007. PMID: 17496168
Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide.
Nicole P, Lins L, Rouyer-Fessard C, Drouot C, Fulcrand P, Thomas A, Couvineau A, Martinez J, Brasseur R, Laburthe M. Nicole P, et al. Among authors: drouot c. J Biol Chem. 2000 Aug 4;275(31):24003-12. doi: 10.1074/jbc.M002325200. J Biol Chem. 2000. PMID: 10801840 Free article.
Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases.
Barelli H, Lebeau A, Vizzavona J, Delaere P, Chevallier N, Drouot C, Marambaud P, Ancolio K, Buxbaum JD, Khorkova O, Heroux J, Sahasrabudhe S, Martinez J, Warter JM, Mohr M, Checler F. Barelli H, et al. Among authors: drouot c. Mol Med. 1997 Oct;3(10):695-707. Mol Med. 1997. PMID: 9392006 Free PMC article.
Some of the amino acid chemistry going on in the Laboratory of Amino Acids, Peptides and Proteins.
Bouifraden S, Drouot C, el Hadrami M, Guenoun F, Lecointe L, Mai N, Paris M, Pothion C, Sadoune M, Sauvagnat B, Amblard M, Aubagnac JL, Calmes M, Chevallet P, Daunis J, Enjalbal C, Fehrentz JA, Lamaty F, Lavergne JP, Lazaro R, Rolland V, Roumestant ML, Viallefont P, Vidal Y, Martinez J. Bouifraden S, et al. Among authors: drouot c. Amino Acids. 1999;16(3-4):345-79. doi: 10.1007/BF01388176. Amino Acids. 1999. PMID: 10399020 Review.