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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Gebregiworgis T, Kano Y, St-Germain J, Radulovich N, Udaskin ML, Mentes A, Huang R, Poon BPK, He W, Valencia-Sama I, Robinson CM, Huestis M, Miao J, Yeh JJ, Zhang ZY, Irwin MS, Lee JE, Tsao MS, Raught B, Marshall CB, Ohh M, Ikura M. Gebregiworgis T, et al. Among authors: raught b. Nat Commun. 2021 Nov 1;12(1):6274. doi: 10.1038/s41467-021-26526-y. Nat Commun. 2021. PMID: 34725361 Free PMC article.
Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.
Bunda S, Heir P, Srikumar T, Cook JD, Burrell K, Kano Y, Lee JE, Zadeh G, Raught B, Ohh M. Bunda S, et al. Among authors: raught b. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3785-94. doi: 10.1073/pnas.1406559111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157176 Free PMC article.
MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.
Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, Rottapel R. Sandí MJ, et al. Among authors: raught b. Sci Signal. 2017 Oct 31;10(503):eaan3286. doi: 10.1126/scisignal.aan3286. Sci Signal. 2017. PMID: 29089450 Free PMC article.
Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus.
Coyaud E, Ranadheera C, Cheng D, Gonçalves J, Dyakov BJA, Laurent EMN, St-Germain J, Pelletier L, Gingras AC, Brumell JH, Kim PK, Safronetz D, Raught B. Coyaud E, et al. Among authors: raught b. Mol Cell Proteomics. 2018 Nov;17(11):2242-2255. doi: 10.1074/mcp.TIR118.000800. Epub 2018 Jul 23. Mol Cell Proteomics. 2018. PMID: 30037810 Free PMC article.
192 results