Clement B - Search Results

1

The Novel Dual Topoisomerase Inhibitor P8-D6 Shows Anti-myeloma Activity In Vitro and In Vivo.

Klausz K, Kellner C, Gehlert CL, Krohn S, Wilcken H, Floerkemeier I, Günther A, Bauerschlag DO, Clement B, Gramatzki M, Peipp M. Klausz K, et al. Among authors: clement b. Mol Cancer Ther. 2022 Jan;21(1):70-78. doi: 10.1158/1535-7163.MCT-21-0119. Epub 2021 Nov 1. Mol Cancer Ther. 2022. PMID: 34725192

2

A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment.

Meier C, Steinhauer TN, Koczian F, Plitzko B, Jarolim K, Girreser U, Braig S, Marko D, Vollmar AM, Clement B. Meier C, et al. Among authors: clement b. ChemMedChem. 2017 Mar 7;12(5):347-352. doi: 10.1002/cmdc.201700026. Epub 2017 Feb 8. ChemMedChem. 2017. PMID: 28099785

3

The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties.

Aichinger G, Lichtenberger FB, Steinhauer TN, Flörkemeier I, Del Favero G, Clement B, Marko D. Aichinger G, et al. Among authors: clement b. Molecules. 2020 Mar 27;25(7):1524. doi: 10.3390/molecules25071524. Molecules. 2020. PMID: 32230817 Free PMC article.

4

Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer.

Flörkemeier I, Steinhauer TN, Hedemann N, Ölander M, Artursson P, Clement B, Bauerschlag DO. Flörkemeier I, et al. Among authors: clement b. Ther Adv Med Oncol. 2021 Nov 25;13:17588359211059896. doi: 10.1177/17588359211059896. eCollection 2021. Ther Adv Med Oncol. 2021. PMID: 34887943 Free PMC article.

5

High Antitumor Activity of the Dual Topoisomerase Inhibitor P8-D6 in Breast Cancer.

Flörkemeier I, Steinhauer TN, Hedemann N, Weimer JP, Rogmans C, van Mackelenbergh MT, Maass N, Clement B, Bauerschlag DO. Flörkemeier I, et al. Among authors: clement b. Cancers (Basel). 2021 Dec 21;14(1):2. doi: 10.3390/cancers14010002. Cancers (Basel). 2021. PMID: 35008166 Free PMC article.

6

Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer.

Flörkemeier I, Hillmann JS, Weimer JP, Hildebrandt J, Hedemann N, Rogmans C, Dempfle A, Arnold N, Clement B, Bauerschlag DO. Flörkemeier I, et al. Among authors: clement b. Int J Mol Sci. 2022 Sep 10;23(18):10503. doi: 10.3390/ijms231810503. Int J Mol Sci. 2022. PMID: 36142413 Free PMC article.

7

Synthesis and biological evaluation of 11-substituted 6-aminobenzo[c]phenanthridine derivatives, a new class of antitumor agents.

Kock I, Heber D, Weide M, Wolschendorf U, Clement B. Kock I, et al. Among authors: clement b. J Med Chem. 2005 Apr 21;48(8):2772-7. doi: 10.1021/jm0490888. J Med Chem. 2005. PMID: 15828815

8

Modulating the NO generating system from a medicinal chemistry perspective: current trends and therapeutic options in cardiovascular disease.

Schade D, Kotthaus J, Clement B. Schade D, et al. Among authors: clement b. Pharmacol Ther. 2010 Jun;126(3):279-300. doi: 10.1016/j.pharmthera.2010.02.005. Epub 2010 Mar 10. Pharmacol Ther. 2010. PMID: 20226211 Review.

9

11-Substituted Benzo[c]phenanthridines: New Structures and Insight into Their Mode of Antiproliferative Action.

Clement B, Girreser U, Steinhauer TN, Meier C, Marko D, Aichinger G, Kaltefleiter I, Stenzel L, Heber D, Weide M, Wolschendorf U, Zebothsen I, Zur Nieden D. Clement B, et al. ChemMedChem. 2016 Oct 6;11(19):2155-2170. doi: 10.1002/cmdc.201600199. Epub 2016 Aug 22. ChemMedChem. 2016. PMID: 27546098

10

The Pharmacokinetics of Fumaric Acid Esters Reveal Their In Vivo Effects.

Mrowietz U, Morrison PJ, Suhrkamp I, Kumanova M, Clement B. Mrowietz U, et al. Among authors: clement b. Trends Pharmacol Sci. 2018 Jan;39(1):1-12. doi: 10.1016/j.tips.2017.11.002. Epub 2017 Nov 25. Trends Pharmacol Sci. 2018. PMID: 29183628 Review.

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