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Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro.
Gil-Moles M, Türck S, Basu U, Pettenuzzo A, Bhattacharya S, Rajan A, Ma X, Büssing R, Wölker J, Burmeister H, Hoffmeister H, Schneeberg P, Prause A, Lippmann P, Kusi-Nimarko J, Hassell-Hart S, McGown A, Guest D, Lin Y, Notaro A, Vinck R, Karges J, Cariou K, Peng K, Qin X, Wang X, Skiba J, Szczupak Ł, Kowalski K, Schatzschneider U, Hemmert C, Gornitzka H, Milaeva ER, Nazarov AA, Gasser G, Spencer J, Ronconi L, Kortz U, Cinatl J, Bojkova D, Ott I. Gil-Moles M, et al. Among authors: cinatl j. Chemistry. 2021 Dec 20;27(71):17928-17940. doi: 10.1002/chem.202103258. Epub 2021 Nov 23. Chemistry. 2021. PMID: 34714566 Free PMC article.
Lack of antiviral activity of darunavir against SARS-CoV-2.
De Meyer S, Bojkova D, Cinatl J, Van Damme E, Buyck C, Van Loock M, Woodfall B, Ciesek S. De Meyer S, et al. Among authors: cinatl j. Int J Infect Dis. 2020 Aug;97:7-10. doi: 10.1016/j.ijid.2020.05.085. Epub 2020 May 29. Int J Infect Dis. 2020. PMID: 32479865 Free PMC article.
In vitro activity of itraconazole against SARS-CoV-2.
Van Damme E, De Meyer S, Bojkova D, Ciesek S, Cinatl J, De Jonghe S, Jochmans D, Leyssen P, Buyck C, Neyts J, Van Loock M. Van Damme E, et al. Among authors: cinatl j. J Med Virol. 2021 Jul;93(7):4454-4460. doi: 10.1002/jmv.26917. J Med Virol. 2021. PMID: 33666253 Free PMC article.
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets.
Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Münch C. Bojkova D, et al. Among authors: cinatl j. Nature. 2020 Jul;583(7816):469-472. doi: 10.1038/s41586-020-2332-7. Epub 2020 May 14. Nature. 2020. PMID: 32408336 Free PMC article.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I. Shin D, et al. Among authors: cinatl j. Nature. 2020 Nov;587(7835):657-662. doi: 10.1038/s41586-020-2601-5. Epub 2020 Jul 29. Nature. 2020. PMID: 32726803 Free PMC article.
Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants.
Bojkova D, Stack R, Rothenburger T, Kandler JD, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. Bojkova D, et al. Among authors: cinatl j jr. J Infect. 2022 Nov;85(5):573-607. doi: 10.1016/j.jinf.2022.07.023. Epub 2022 Jul 31. J Infect. 2022. PMID: 35917841 Free PMC article. No abstract available.
Aprotinin Inhibits SARS-CoV-2 Replication.
Bojkova D, Bechtel M, McLaughlin KM, McGreig JE, Klann K, Bellinghausen C, Rohde G, Jonigk D, Braubach P, Ciesek S, Münch C, Wass MN, Michaelis M, Cinatl J Jr. Bojkova D, et al. Among authors: cinatl j jr. Cells. 2020 Oct 30;9(11):2377. doi: 10.3390/cells9112377. Cells. 2020. PMID: 33143316 Free PMC article.
465 results