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p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. Sturmlechner I, et al. Among authors: laberge rm. Science. 2021 Oct 29;374(6567):eabb3420. doi: 10.1126/science.abb3420. Epub 2021 Oct 29. Science. 2021. PMID: 34709885 Free PMC article.
Senescent cells: an emerging target for diseases of ageing.
Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM. Childs BG, et al. Among authors: laberge rm. Nat Rev Drug Discov. 2017 Oct;16(10):718-735. doi: 10.1038/nrd.2017.116. Epub 2017 Jul 21. Nat Rev Drug Discov. 2017. PMID: 28729727 Free PMC article. Review.
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence.
López-Domínguez JA, Rodríguez-López S, Ahumada-Castro U, Desprez PY, Konovalenko M, Laberge RM, Cárdenas C, Villalba JM, Campisi J. López-Domínguez JA, et al. Among authors: laberge rm. Aging (Albany NY). 2021 May 25;13(10):13380-13392. doi: 10.18632/aging.203110. Epub 2021 May 25. Aging (Albany NY). 2021. PMID: 34035185 Free PMC article.
Lamin B1 loss is a senescence-associated biomarker.
Freund A, Laberge RM, Demaria M, Campisi J. Freund A, et al. Among authors: laberge rm. Mol Biol Cell. 2012 Jun;23(11):2066-75. doi: 10.1091/mbc.E11-10-0884. Epub 2012 Apr 11. Mol Biol Cell. 2012. PMID: 22496421 Free PMC article.
p53: Pro-aging or pro-longevity?
de Keizer PL, Laberge RM, Campisi J. de Keizer PL, et al. Among authors: laberge rm. Aging (Albany NY). 2010 Jul;2(7):377-9. doi: 10.18632/aging.100178. Aging (Albany NY). 2010. PMID: 20657035 Free PMC article. No abstract available.
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J. Demaria M, et al. Among authors: laberge rm. Dev Cell. 2014 Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11. Dev Cell. 2014. PMID: 25499914 Free PMC article.
26 results