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Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types.
Umar S, Palasiewicz K, Volin MV, Romay B, Rahat R, Tetali C, Arami S, Guma M, Ascoli C, Sweiss N, Zomorrodi RK, O'Neill LAJ, Shahrara S. Umar S, et al. Cell Mol Life Sci. 2021 Dec;78(23):7693-7707. doi: 10.1007/s00018-021-03978-5. Epub 2021 Oct 27. Cell Mol Life Sci. 2021. PMID: 34705053 Free PMC article.
Regulators of TLR4 signaling by endotoxins.
McGettrick AF, O'Neill LA. McGettrick AF, et al. Subcell Biochem. 2010;53:153-71. doi: 10.1007/978-90-481-9078-2_7. Subcell Biochem. 2010. PMID: 20593266 Review.
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. Tannahill GM, et al. Nature. 2013 Apr 11;496(7444):238-42. doi: 10.1038/nature11986. Epub 2013 Mar 24. Nature. 2013. PMID: 23535595 Free PMC article.
446 results