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Page 1
Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria.
Sharma S, Rao R, Reeve SM, Phelps GA, Bharatham N, Katagihallimath N, Ramachandran V, Raveendran S, Sarma M, Nath A, Thomas T, Manickam D, Nagaraj S, Balasubramanian V, Lee RE, Hameed P S, Datta S. Sharma S, et al. Among authors: bharatham n. ACS Infect Dis. 2021 Nov 12;7(11):3009-3024. doi: 10.1021/acsinfecdis.1c00171. Epub 2021 Oct 26. ACS Infect Dis. 2021. PMID: 34699190
Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.
Bharatham N, Bhowmik P, Aoki M, Okada U, Sharma S, Yamashita E, Shanbhag AP, Rajagopal S, Thomas T, Sarma M, Narjari R, Nagaraj S, Ramachandran V, Katagihallimath N, Datta S, Murakami S. Bharatham N, et al. Nat Commun. 2021 Sep 13;12(1):5400. doi: 10.1038/s41467-021-25679-0. Nat Commun. 2021. PMID: 34518546 Free PMC article.
Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy.
Hameed P S, Bharatham N, Katagihallimath N, Sharma S, Nandishaiah R, Shanbhag AP, Thomas T, Narjari R, Sarma M, Bhowmik P, Amar P, Ravishankar R, Jayaraman R, Muthan K, Subbiah R, Ramachandran V, Balasubramanian V, Datta S. Hameed P S, et al. Among authors: bharatham n. Sci Rep. 2018 May 8;8(1):7263. doi: 10.1038/s41598-018-25407-7. Sci Rep. 2018. PMID: 29740005 Free PMC article.
Combating Multidrug-Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling.
Lang Y, Shah NR, Tao X, Reeve SM, Zhou J, Moya B, Sayed ARM, Dharuman S, Oyer JL, Copik AJ, Fleischer BA, Shin E, Werkman C, Basso KB, Deveson Lucas D, Sutaria DS, Mégroz M, Kim TH, Loudon-Hossler V, Wright A, Jimenez-Nieves RH, Wallace MJ, Cadet KC, Jiao Y, Boyce JD, LoVullo ED, Schweizer HP, Bonomo RA, Bharatham N, Tsuji BT, Landersdorfer CB, Norris MH, Soo Shin B, Louie A, Balasubramanian V, Lee RE, Drusano GL, Bulitta JB. Lang Y, et al. Among authors: bharatham n. Clin Pharmacol Ther. 2021 Apr;109(4):1000-1020. doi: 10.1002/cpt.2205. Epub 2021 Mar 24. Clin Pharmacol Ther. 2021. PMID: 33576025 Free PMC article.
A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation.
Haq SF, Shanbhag AP, Karthikeyan S, Hassan I, Thanukrishnan K, Ashok A, Sukumaran S, Ramaswamy S, Bharatham N, Datta S, Samant S, Katagihallimath N. Haq SF, et al. Among authors: bharatham n. Microb Cell Fact. 2018 Dec 3;17(1):192. doi: 10.1186/s12934-018-1036-2. Microb Cell Fact. 2018. PMID: 30509260 Free PMC article.
Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.
Slavish PJ, Chi L, Yun MK, Tsurkan L, Martinez NE, Jonchere B, Chai SC, Connelly M, Waddell MB, Das S, Neale G, Li Z, Shadrick WR, Olsen RR, Freeman KW, Low JA, Price JE, Young BM, Bharatham N, Boyd VA, Yang J, Lee RE, Morfouace M, Roussel MF, Chen T, Savic D, Guy RK, White SW, Shelat AA, Potter PM. Slavish PJ, et al. Among authors: bharatham n. Cancer Res. 2020 Sep 1;80(17):3507-3518. doi: 10.1158/0008-5472.CAN-19-3934. Epub 2020 Jul 10. Cancer Res. 2020. PMID: 32651255 Free PMC article.
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Shadrick WR, Slavish PJ, Chai SC, Waddell B, Connelly M, Low JA, Tallant C, Young BM, Bharatham N, Knapp S, Boyd VA, Morfouace M, Roussel MF, Chen T, Lee RE, Kiplin Guy R, Shelat AA, Potter PM. Shadrick WR, et al. Among authors: bharatham n. Bioorg Med Chem. 2018 Jan 1;26(1):25-36. doi: 10.1016/j.bmc.2017.10.042. Epub 2017 Nov 4. Bioorg Med Chem. 2018. PMID: 29170024 Free PMC article.
31 results