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Glycogen accumulation and phase separation drives liver tumor initiation.
Liu Q, Li J, Zhang W, Xiao C, Zhang S, Nian C, Li J, Su D, Chen L, Zhao Q, Shao H, Zhao H, Chen Q, Li Y, Geng J, Hong L, Lin S, Wu Q, Deng X, Ke R, Ding J, Johnson RL, Liu X, Chen L, Zhou D. Liu Q, et al. Among authors: chen l, chen q. Cell. 2021 Oct 28;184(22):5559-5576.e19. doi: 10.1016/j.cell.2021.10.001. Epub 2021 Oct 21. Cell. 2021. PMID: 34678143 Free article.
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L, Zhou D. Wu H, et al. Among authors: chen l, chen q. Nat Commun. 2015 Feb 19;6:6239. doi: 10.1038/ncomms7239. Nat Commun. 2015. PMID: 25695629 Free article.
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.
Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L, Zhou D. Geng J, et al. Among authors: chen l, chen q. Nat Immunol. 2015 Nov;16(11):1142-52. doi: 10.1038/ni.3268. Epub 2015 Sep 28. Nat Immunol. 2015. PMID: 26414765 Free PMC article.
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
Fan F, He Z, Kong LL, Chen Q, Yuan Q, Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia NS, Gray NS, Chen L, Yun CH, Deng X, Zhou D. Fan F, et al. Among authors: chen l, chen q. Sci Transl Med. 2016 Aug 17;8(352):352ra108. doi: 10.1126/scitranslmed.aaf2304. Sci Transl Med. 2016. PMID: 27535619
Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.
Zhang S, Chen Q, Liu Q, Li Y, Sun X, Hong L, Ji S, Liu C, Geng J, Zhang W, Lu Z, Yin ZY, Zeng Y, Lin KH, Wu Q, Li Q, Nakayama K, Nakayama KI, Deng X, Johnson RL, Zhu L, Gao D, Chen L, Zhou D. Zhang S, et al. Among authors: chen l, chen q. Cancer Cell. 2017 May 8;31(5):669-684.e7. doi: 10.1016/j.ccell.2017.04.004. Cancer Cell. 2017. PMID: 28486106 Free PMC article.
The Hippo Signaling Pathway in Regenerative Medicine.
Hong L, Li Y, Liu Q, Chen Q, Chen L, Zhou D. Hong L, et al. Among authors: chen l, chen q. Methods Mol Biol. 2019;1893:353-370. doi: 10.1007/978-1-4939-8910-2_26. Methods Mol Biol. 2019. PMID: 30565146
FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis.
Ji S, Liu Q, Zhang S, Chen Q, Wang C, Zhang W, Xiao C, Li Y, Nian C, Li J, Li J, Geng J, Hong L, Xie C, He Y, Chen X, Li X, Yin ZY, You H, Lin KH, Wu Q, Yu C, Johnson RL, Wang L, Chen L, Wang F, Zhou D. Ji S, et al. Among authors: chen l, chen q, chen x. Dev Cell. 2019 Feb 25;48(4):460-474.e9. doi: 10.1016/j.devcel.2018.12.021. Epub 2019 Feb 7. Dev Cell. 2019. PMID: 30745141 Free article.
SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling.
Su D, Li Y, Zhang W, Gao H, Cheng Y, Hou Y, Li J, Ye Y, Lai Z, Li Z, Huang H, Li J, Li J, Cheng M, Nian C, Wu N, Zhou Z, Xing Y, Zhao Y, Liu H, Tang J, Chen Q, Hong L, Li W, Peng Z, Zhao B, Johnson RL, Liu P, Hong W, Chen L, Zhou D. Su D, et al. Among authors: chen l, chen q. J Clin Invest. 2023 Oct 16;133(20):e168888. doi: 10.1172/JCI168888. J Clin Invest. 2023. PMID: 37843276 Free PMC article.
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