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Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ).
Mata G, Miles DH, Drew SL, Fournier J, Lawson KV, Mailyan AK, Sharif EU, Yan X, Beatty JW, Banuelos J, Chen J, Ginn E, Chen A, Gerrick KY, Pham AT, Wong K, Soni D, Dhanota P, Shaqfeh SG, Meleza C, Narasappa N, Singh H, Zhao X, Jin L, Schindler U, Walters MJ, Young SW, Walker NP, Leleti MR, Powers JP, Jeffrey JL. Mata G, et al. Among authors: shaqfeh sg. J Med Chem. 2022 Jan 27;65(2):1418-1444. doi: 10.1021/acs.jmedchem.1c01153. Epub 2021 Oct 21. J Med Chem. 2022. PMID: 34672584
Discovery of Potent and Selective PI3Kγ Inhibitors.
Drew SL, Thomas-Tran R, Beatty JW, Fournier J, Lawson KV, Miles DH, Mata G, Sharif EU, Yan X, Mailyan AK, Ginn E, Chen J, Wong K, Soni D, Dhanota P, Chen PY, Shaqfeh SG, Meleza C, Pham AT, Chen A, Zhao X, Banuelos J, Jin L, Schindler U, Walters MJ, Young SW, Walker NP, Leleti MR, Powers JP, Jeffrey JL. Drew SL, et al. Among authors: shaqfeh sg. J Med Chem. 2020 Oct 8;63(19):11235-11257. doi: 10.1021/acs.jmedchem.0c01203. Epub 2020 Sep 16. J Med Chem. 2020. PMID: 32865410 Free article.
Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors.
Miles DH, Yan X, Thomas-Tran R, Fournier J, Sharif EU, Drew SL, Mata G, Lawson KV, Ginn E, Wong K, Soni D, Dhanota P, Shaqfeh SG, Meleza C, Chen A, Pham AT, Park T, Swinarski D, Banuelos J, Schindler U, Walters MJ, Walker NP, Zhao X, Young SW, Chen J, Jin L, Leleti MR, Powers JP, Jeffrey JL. Miles DH, et al. Among authors: shaqfeh sg. ACS Med Chem Lett. 2020 Sep 24;11(11):2244-2252. doi: 10.1021/acsmedchemlett.0c00387. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214836 Free PMC article.