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Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection.
Vu MN, Alvarado RE, Morris DR, Lokugamage KG, Zhou Y, Morgan AL, Estes LK, McLeland AM, Schindewolf C, Plante JA, Ahearn YP, Meyers WM, Murray JT, Crocquet-Valdes PA, Weaver SC, Walker DH, Russell WK, Routh AL, Plante KS, Menachery V. Vu MN, et al. Among authors: schindewolf c. bioRxiv [Preprint]. 2023 Jul 10:2023.04.17.536926. doi: 10.1101/2023.04.17.536926. bioRxiv. 2023. PMID: 37131784 Free PMC article. Preprint.
Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro.
Hou N, Shuai L, Zhang L, Xie X, Tang K, Zhu Y, Yu Y, Zhang W, Tan Q, Zhong G, Wen Z, Wang C, He X, Huo H, Gao H, Xu Y, Xue J, Peng C, Zou J, Schindewolf C, Menachery V, Su W, Yuan Y, Shen Z, Zhang R, Yuan S, Yu H, Shi PY, Bu Z, Huang J, Hu Q. Hou N, et al. Among authors: schindewolf c. ACS Cent Sci. 2023 Jan 25;9(2):217-227. doi: 10.1021/acscentsci.2c01359. eCollection 2023 Feb 22. ACS Cent Sci. 2023. PMID: 36844503 Free PMC article.
SARS-CoV-2 Uses Nonstructural Protein 16 To Evade Restriction by IFIT1 and IFIT3.
Schindewolf C, Lokugamage K, Vu MN, Johnson BA, Scharton D, Plante JA, Kalveram B, Crocquet-Valdes PA, Sotcheff S, Jaworski E, Alvarado RE, Debbink K, Daugherty MD, Weaver SC, Routh AL, Walker DH, Plante KS, Menachery VD. Schindewolf C, et al. J Virol. 2023 Feb 28;97(2):e0153222. doi: 10.1128/jvi.01532-22. Epub 2023 Feb 1. J Virol. 2023. PMID: 36722972 Free PMC article.
SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3.
Schindewolf C, Lokugamage K, Vu MN, Johnson BA, Scharton D, Plante JA, Kalveram B, Crocquet-Valdes PA, Sotcheff S, Jaworski E, Alvarado RE, Debbink K, Daugherty MD, Weaver SC, Routh AL, Walker DH, Plante KS, Menachery VD. Schindewolf C, et al. bioRxiv [Preprint]. 2022 Sep 26:2022.09.26.509529. doi: 10.1101/2022.09.26.509529. bioRxiv. 2022. Update in: J Virol. 2023 Feb 28;97(2):e0153222. doi: 10.1128/jvi.01532-22 PMID: 36203546 Free PMC article. Updated. Preprint.
QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis.
Vu MN, Lokugamage KG, Plante JA, Scharton D, Bailey AO, Sotcheff S, Swetnam DM, Johnson BA, Schindewolf C, Alvarado RE, Crocquet-Valdes PA, Debbink K, Weaver SC, Walker DH, Russell WK, Routh AL, Plante KS, Menachery VD. Vu MN, et al. Among authors: schindewolf c. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2205690119. doi: 10.1073/pnas.2205690119. Epub 2022 Jul 26. Proc Natl Acad Sci U S A. 2022. PMID: 35881779 Free PMC article.
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
Johnson BA, Zhou Y, Lokugamage KG, Vu MN, Bopp N, Crocquet-Valdes PA, Kalveram B, Schindewolf C, Liu Y, Scharton D, Plante JA, Xie X, Aguilar P, Weaver SC, Shi PY, Walker DH, Routh AL, Plante KS, Menachery VD. Johnson BA, et al. Among authors: schindewolf c. PLoS Pathog. 2022 Jun 21;18(6):e1010627. doi: 10.1371/journal.ppat.1010627. eCollection 2022 Jun. PLoS Pathog. 2022. PMID: 35728038 Free PMC article.
Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.
Liu Y, Liu J, Johnson BA, Xia H, Ku Z, Schindewolf C, Widen SG, An Z, Weaver SC, Menachery VD, Xie X, Shi PY. Liu Y, et al. Among authors: schindewolf c. Cell Rep. 2022 May 17;39(7):110829. doi: 10.1016/j.celrep.2022.110829. Epub 2022 Apr 29. Cell Rep. 2022. PMID: 35550680 Free PMC article.
The N501Y spike substitution enhances SARS-CoV-2 infection and transmission.
Liu Y, Liu J, Plante KS, Plante JA, Xie X, Zhang X, Ku Z, An Z, Scharton D, Schindewolf C, Widen SG, Menachery VD, Shi PY, Weaver SC. Liu Y, et al. Among authors: schindewolf c. Nature. 2022 Feb;602(7896):294-299. doi: 10.1038/s41586-021-04245-0. Epub 2021 Nov 24. Nature. 2022. PMID: 34818667 Free PMC article.
30 results