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A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.
Chen W, Ohara N, Wang J, Xu Q, Liu J, Morikawa A, Sasaki H, Yoshida S, Demanno DA, Chwalisz K, Maruo T. Chen W, et al. J Clin Endocrinol Metab. 2006 Apr;91(4):1296-304. doi: 10.1210/jc.2005-2379. Epub 2006 Feb 7. J Clin Endocrinol Metab. 2006. PMID: 16464945
Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells.
Xu Q, Takekida S, Ohara N, Chen W, Sitruk-Ware R, Johansson ED, Maruo T. Xu Q, et al. Among authors: chen w. J Clin Endocrinol Metab. 2005 Feb;90(2):953-61. doi: 10.1210/jc.2004-1569. Epub 2004 Nov 30. J Clin Endocrinol Metab. 2005. PMID: 15572421
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