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The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.
Giblin W, Bringman-Rodenbarger L, Guo AH, Kumar S, Monovich AC, Mostafa AM, Skinner ME, Azar M, Mady AS, Chung CH, Kadambi N, Melong KA, Lee HJ, Zhang L, Sajjakulnukit P, Trefely S, Varner EL, Iyer S, Wang M, Wilmott JS, Soyer HP, Sturm RA, Pritchard AL, Andea AA, Scolyer RA, Stark MS, Scott DA, Fullen DR, Bosenberg MW, Chandrasekaran S, Nikolovska-Coleska Z, Verhaegen ME, Snyder NW, Rivera MN, Osterman AL, Lyssiotis CA, Lombard DB. Giblin W, et al. Among authors: varner el. J Clin Invest. 2021 Jun 15;131(12):e138926. doi: 10.1172/JCI138926. J Clin Invest. 2021. PMID: 33945506 Free PMC article.
Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species.
Doan MT, Neinast MD, Varner EL, Bedi KC Jr, Bartee D, Jiang H, Trefely S, Xu P, Singh JP, Jang C, Rame JE, Brady DC, Meier JL, Marguiles KB, Arany Z, Snyder NW. Doan MT, et al. Among authors: varner el. J Lipid Res. 2022 Jun;63(6):100224. doi: 10.1016/j.jlr.2022.100224. Epub 2022 May 11. J Lipid Res. 2022. PMID: 35568254 Free PMC article.
ATM inhibition drives metabolic adaptation via induction of macropinocytosis.
Huang Z, Chen CW, Buj R, Tangudu NK, Fang RS, Leon KE, Dahl ES, Varner EL, von Krusenstiern E, Cole AR, Snyder NW, Aird KM. Huang Z, et al. Among authors: varner el. J Cell Biol. 2023 Jan 2;222(1):e202007026. doi: 10.1083/jcb.202007026. Epub 2022 Nov 18. J Cell Biol. 2023. PMID: 36399181 Free PMC article.
16 results