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Vitamin D deficiency after allogeneic hematopoietic cell transplantation promotes T-cell activation and is inversely associated with an EZH2-ID3 signature.
Macedo R, Pasin C, Ganetsky A, Harle D, Wang XK, Belay K, Richman LP, Huffman AP, Vonderheide RH, Yates AJ, Porter DL, Wang Y, Zhang Y, Reshef R. Macedo R, et al. Among authors: zhang y. Transplant Cell Ther. 2022 Jan;28(1):18.e1-18.e10. doi: 10.1016/j.jtct.2021.09.017. Epub 2021 Sep 28. Transplant Cell Ther. 2022. PMID: 34597852 Free PMC article.
Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation.
Hexner EO, Danet-Desnoyers GA, Zhang Y, Frank DM, Riley JL, Levine BL, Porter DL, June CH, Emerson SG. Hexner EO, et al. Among authors: zhang y. Biol Blood Marrow Transplant. 2007 Oct;13(10):1135-44. doi: 10.1016/j.bbmt.2007.06.010. Biol Blood Marrow Transplant. 2007. PMID: 17889349 Free article.
The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation.
Meng L, Bai Z, He S, Mochizuki K, Liu Y, Purushe J, Sun H, Wang J, Yagita H, Mineishi S, Fung H, Yanik GA, Caricchio R, Fan X, Crisalli LM, Hexner EO, Reshef R, Zhang Y, Zhang Y. Meng L, et al. Among authors: zhang y. J Immunol. 2016 Feb 1;196(3):1070-80. doi: 10.4049/jimmunol.1501310. Epub 2015 Dec 28. J Immunol. 2016. PMID: 26712946 Free PMC article.
Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.
Hexner EO, Luger SM, Reshef R, Jeschke GR, Mangan JK, Frey NV, Frank DM, Richman LP, Vonderheide RH, Aqui NA, Rosenbach M, Zhang Y, Chew A, Loren AW, Stadtmauer EA, Levine BL, June CH, Emerson SG, Porter DL. Hexner EO, et al. Among authors: zhang y. Am J Hematol. 2016 May;91(5):453-60. doi: 10.1002/ajh.24303. Epub 2016 Apr 4. Am J Hematol. 2016. PMID: 26858124 Free PMC article. Clinical Trial.
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