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An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats.
Kamiya Y, Handa K, Miura T, Ohori J, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: kitajima m. Chem Res Toxicol. 2021 Oct 18;34(10):2180-2183. doi: 10.1021/acs.chemrestox.1c00249. Epub 2021 Sep 29. Chem Res Toxicol. 2021. PMID: 34586804
Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling.
Takano R, Murayama N, Horiuchi K, Kitajima M, Kumamoto M, Shono F, Yamazaki H. Takano R, et al. Among authors: kitajima m. Regul Toxicol Pharmacol. 2010 Nov;58(2):252-8. doi: 10.1016/j.yrtph.2010.06.008. Epub 2010 Jun 23. Regul Toxicol Pharmacol. 2010. PMID: 20600458
Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling.
Yamazaki H, Horiuchi K, Takano R, Nagano T, Shimizu M, Kitajima M, Murayama N, Shono F. Yamazaki H, et al. Among authors: kitajima m. Int J Environ Res Public Health. 2010 Sep;7(9):3406-21. doi: 10.3390/ijerph7093406. Epub 2010 Sep 1. Int J Environ Res Public Health. 2010. PMID: 20948932 Free PMC article.
Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.
Kamiya Y, Takaku H, Yamada R, Akase C, Abe Y, Sekiguchi Y, Murayama N, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: kitajima m. Toxicol Rep. 2020 Jan 14;7:149-154. doi: 10.1016/j.toxrep.2020.01.004. eCollection 2020. Toxicol Rep. 2020. PMID: 31993333 Free PMC article.
Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats.
Kamiya Y, Otsuka S, Miura T, Yoshizawa M, Nakano A, Iwasaki M, Kobayashi Y, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: kitajima m. Chem Res Toxicol. 2020 Jul 20;33(7):1736-1751. doi: 10.1021/acs.chemrestox.0c00009. Epub 2020 Jun 19. Chem Res Toxicol. 2020. PMID: 32500706
In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals.
Kamiya Y, Handa K, Miura T, Yanagi M, Shigeta K, Hina S, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: kitajima m. Chem Res Toxicol. 2021 Feb 15;34(2):507-513. doi: 10.1021/acs.chemrestox.0c00336. Epub 2021 Jan 12. Chem Res Toxicol. 2021. PMID: 33433197
Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning.
Kamiya Y, Omura A, Hayasaka R, Saito R, Sano I, Handa K, Ohori J, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: kitajima m. Biochem Pharmacol. 2021 Oct;192:114749. doi: 10.1016/j.bcp.2021.114749. Epub 2021 Aug 27. Biochem Pharmacol. 2021. PMID: 34461115
Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals.
Kamiya Y, Handa K, Miura T, Ohori J, Kato A, Shimizu M, Kitajima M, Yamazaki H. Kamiya Y, et al. Among authors: kitajima m. Biol Pharm Bull. 2022 Jan 1;45(1):124-128. doi: 10.1248/bpb.b21-00769. Epub 2021 Nov 2. Biol Pharm Bull. 2022. PMID: 34732590 Free article.
Correction to "An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats".
Kamiya Y, Handa K, Miura T, Ohori J, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: kitajima m. Chem Res Toxicol. 2022 Aug 15;35(8):1433. doi: 10.1021/acs.chemrestox.2c00225. Epub 2022 Jul 29. Chem Res Toxicol. 2022. PMID: 35905009 No abstract available.
1,479 results