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An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats.
Kamiya Y, Handa K, Miura T, Ohori J, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Chem Res Toxicol. 2021 Oct 18;34(10):2180-2183. doi: 10.1021/acs.chemrestox.1c00249. Epub 2021 Sep 29. Chem Res Toxicol. 2021. PMID: 34586804
Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate.
Miura T, Uehara S, Mizuno S, Yoshizawa M, Murayama N, Kamiya Y, Shimizu M, Suemizu H, Yamazaki H. Miura T, et al. Among authors: kamiya y. Chem Res Toxicol. 2019 Feb 18;32(2):333-340. doi: 10.1021/acs.chemrestox.8b00361. Epub 2019 Feb 5. Chem Res Toxicol. 2019. PMID: 30652481
Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.
Kamiya Y, Takaku H, Yamada R, Akase C, Abe Y, Sekiguchi Y, Murayama N, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Toxicol Rep. 2020 Jan 14;7:149-154. doi: 10.1016/j.toxrep.2020.01.004. eCollection 2020. Toxicol Rep. 2020. PMID: 31993333 Free PMC article.
Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential.
Miura T, Shimizu M, Uehara S, Yoshizawa M, Nakano A, Yanagi M, Kamiya Y, Murayama N, Suemizu H, Yamazaki H. Miura T, et al. Among authors: kamiya y. Chem Res Toxicol. 2020 Dec 21;33(12):3048-3053. doi: 10.1021/acs.chemrestox.0c00387. Epub 2020 Dec 6. Chem Res Toxicol. 2020. PMID: 33283517
In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals.
Kamiya Y, Handa K, Miura T, Yanagi M, Shigeta K, Hina S, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Chem Res Toxicol. 2021 Feb 15;34(2):507-513. doi: 10.1021/acs.chemrestox.0c00336. Epub 2021 Jan 12. Chem Res Toxicol. 2021. PMID: 33433197
925 results