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Page 1
Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.
Bursavich MG, Harrison BA, Acharya R, Costa DE, Freeman EA, Hrdlicka LA, Jin H, Kapadnis S, Moffit JS, Murphy D, Nolan SJ, Patzke H, Tang C, Van Voorhies HE, Wen M, Koenig G, Blain JF, Burnett DA. Bursavich MG, et al. Among authors: freeman ea. J Med Chem. 2021 Oct 14;64(19):14426-14447. doi: 10.1021/acs.jmedchem.1c00904. Epub 2021 Sep 22. J Med Chem. 2021. PMID: 34550687
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
Blain JF, Bursavich MG, Freeman EA, Hrdlicka LA, Hodgdon HE, Chen T, Costa DE, Harrison BA, Kapadnis S, Murphy DA, Nolan S, Tu Z, Tang C, Burnett DA, Patzke H, Koenig G. Blain JF, et al. Among authors: freeman ea. Alzheimers Res Ther. 2016 Aug 30;8(1):34. doi: 10.1186/s13195-016-0199-5. Alzheimers Res Ther. 2016. PMID: 27572246 Free PMC article.
Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.
Bursavich MG, Harrison BA, Acharya R, Costa DE, Freeman EA, Hodgdon HE, Hrdlicka LA, Jin H, Kapadnis S, Moffit JS, Murphy DA, Nolan S, Patzke H, Tang C, Wen M, Koenig G, Blain JF, Burnett DA. Bursavich MG, et al. Among authors: freeman ea. J Med Chem. 2017 Mar 23;60(6):2383-2400. doi: 10.1021/acs.jmedchem.6b01620. Epub 2017 Mar 10. J Med Chem. 2017. PMID: 28230986
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.
Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S, Miller MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF, Freeman E, De Strooper B, Vulsteke V, Scrocchi L, Zetterberg H, Portelius E, Hutter-Paier B, Havas D, Ahlijanian M, Flood D, Leventhal L, Shapiro G, Patzke H, Chesworth R, Koenig G. Rogers K, et al. Mol Neurodegener. 2012 Dec 18;7:61. doi: 10.1186/1750-1326-7-61. Mol Neurodegener. 2012. PMID: 23249765 Free PMC article.
MEK1/2 activity modulates TREM2 cell surface recruitment.
Schapansky J, Grinberg YY, Osiecki DM, Freeman EA, Walker SG, Karran E, Gopalakrishnan SM, Talanian RV. Schapansky J, et al. Among authors: freeman ea. J Biol Chem. 2021 Jan-Jun;296:100218. doi: 10.1074/jbc.RA120.014352. Epub 2020 Dec 25. J Biol Chem. 2021. PMID: 33839686 Free PMC article.
Perspectives on the manipulation of mosquito hearing.
Freeman EA, Ellis DA, Bagi J, Tytheridge S, Andrés M. Freeman EA, et al. Curr Opin Insect Sci. 2024 Dec;66:101271. doi: 10.1016/j.cois.2024.101271. Epub 2024 Sep 21. Curr Opin Insect Sci. 2024. PMID: 39313114 Free article. Review.
Capturing the catalytic intermediates of parkin ubiquitination.
Connelly EM, Rintala-Dempsey AC, Gundogdu M, Freeman EA, Koszela J, Aguirre JD, Zhu G, Kämäräinen O, Tadayon R, Walden H, Shaw GS. Connelly EM, et al. Among authors: freeman ea. Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2403114121. doi: 10.1073/pnas.2403114121. Epub 2024 Jul 30. Proc Natl Acad Sci U S A. 2024. PMID: 39078678
39 results