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S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis.
Ye F, Lin X, Chen Z, Yang F, Lin S, Yang J, Chen H, Sun H, Wang L, Wen A, Zhang X, Dai Y, Cao Y, Yang J, Shen G, Yang L, Li J, Wang Z, Wang W, Wei X, Lu G. Ye F, et al. Among authors: wang w, wang l, wang z. Signal Transduct Target Ther. 2021 Sep 16;6(1):343. doi: 10.1038/s41392-021-00756-4. Signal Transduct Target Ther. 2021. PMID: 34531369 Free PMC article.
Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.
Yue D, Chen Z, Yang F, Ye F, Lin S, He B, Cheng Y, Wang J, Chen Z, Lin X, Yang J, Chen H, Zhang Z, You Y, Sun H, Wen A, Wang L, Zheng Y, Cao Y, Li Y, Lu G. Yue D, et al. Among authors: wang l, wang j. Sci Adv. 2020 May 13;6(20):eaba5147. doi: 10.1126/sciadv.aba5147. eCollection 2020 May. Sci Adv. 2020. PMID: 32426511 Free PMC article.
A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding.
Yang J, Lin S, Sun H, Chen Z, Yang F, Lin X, Guo L, Wang L, Wen A, Zhang X, Dai Y, He B, Cao Y, Dong H, Liu X, Chen B, Li J, Zhao Q, Lu G. Yang J, et al. Among authors: wang l. Front Immunol. 2022 May 18;13:820336. doi: 10.3389/fimmu.2022.820336. eCollection 2022. Front Immunol. 2022. PMID: 35663966 Free PMC article.
An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry.
Lin X, Guo L, Lin S, Chen Z, Yang F, Yang J, Wang L, Wen A, Duan Y, Zhang X, Dai Y, Yin K, Yuan X, Yu C, He B, Cao Y, Dong H, Li J, Zhao Q, Lu G. Lin X, et al. Among authors: wang l. Emerg Microbes Infect. 2022 Dec;11(1):1920-1935. doi: 10.1080/22221751.2022.2095308. Emerg Microbes Infect. 2022. PMID: 35757908 Free PMC article.
Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Chen H, Lin S, Yang F, Chen Z, Guo L, Yang J, Lin X, Wang L, Duan Y, Wen A, Zhang X, Dai Y, Yin K, Yuan X, Yu C, He Y, He B, Cao Y, Dong H, Li J, Zhao Q, Liu Q, Lu G. Chen H, et al. Among authors: wang l. PLoS Pathog. 2023 Oct 13;19(10):e1011694. doi: 10.1371/journal.ppat.1011694. eCollection 2023 Oct. PLoS Pathog. 2023. PMID: 37831643 Free PMC article.
Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization.
Yang J, Lin S, Chen Z, Yang F, Guo L, Wang L, Duan Y, Zhang X, Dai Y, Yin K, Yu C, Yuan X, Sun H, He B, Cao Y, Ye H, Dong H, Liu X, Chen B, Li J, Zhao Q, Lu G. Yang J, et al. Among authors: wang l. PLoS Pathog. 2023 Nov 30;19(11):e1011804. doi: 10.1371/journal.ppat.1011804. eCollection 2023 Nov. PLoS Pathog. 2023. PMID: 38033141 Free PMC article.
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