Kedika SR - Search Results

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A novel peptidomimetic therapeutic for selective suppression of lung cancer stem cells over non-stem cancer cells.

Shukla SP, Raymond A, Rustagi V, Kedika SR, Tran O, Wang L, Guo B, Udugamasooriya DG. Shukla SP, et al. Among authors: kedika sr. Bioorg Chem. 2021 Nov;116:105340. doi: 10.1016/j.bioorg.2021.105340. Epub 2021 Sep 8. Bioorg Chem. 2021. PMID: 34530236 Free PMC article.

Design of a dual ERK5 kinase activation and autophosphorylation inhibitor to block cancer stem cell activity.

Kedika SR, Shukla SP, Udugamasooriya DG. Kedika SR, et al. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127552. doi: 10.1016/j.bmcl.2020.127552. Epub 2020 Sep 15. Bioorg Med Chem Lett. 2020. PMID: 32946922

Converting a weaker ATP-binding site inhibitor into a potent hetero-bivalent ligand by tethering to a unique peptide sequence derived from the same kinase.

Kedika SR, Udugamasooriya DG. Kedika SR, et al. Org Biomol Chem. 2018 Sep 11;16(35):6443-6449. doi: 10.1039/c8ob01406j. Org Biomol Chem. 2018. PMID: 30140808

Chemopreventive Agent 3,3'-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells.

Gao X, Liu J, Cho KB, Kedika S, Guo B. Gao X, et al. Int J Mol Sci. 2020 Jun 30;21(13):4642. doi: 10.3390/ijms21134642. Int J Mol Sci. 2020. PMID: 32629830 Free PMC article.

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