Yan P - Search Results

1

Safety, Pharmacokinetics, and Pharmacodynamics of a Single Bolus of the γ-aminobutyric Acid (GABA) Receptor Potentiator HSK3486 in Healthy Chinese Elderly and Non-elderly.

Li X, Yang D, Li Q, Wang H, Wang M, Yan P, Wu N, Li F, Ma S, Ding Y, Liu J, Wang H. Li X, et al. Among authors: yan p. Front Pharmacol. 2021 Aug 27;12:735700. doi: 10.3389/fphar.2021.735700. eCollection 2021. Front Pharmacol. 2021. PMID: 34512361 Free PMC article.

2

Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects.

Bian Y, Zhang H, Ma S, Jiao Y, Yan P, Liu X, Ma S, Xiong Y, Gu Z, Yu Z, Huang C, Miao L. Bian Y, et al. Among authors: yan p. Br J Clin Pharmacol. 2021 Jan;87(1):93-105. doi: 10.1111/bcp.14363. Epub 2020 Aug 3. Br J Clin Pharmacol. 2021. PMID: 32415708 Free article. Clinical Trial.

3

Safety, pharmacokinetics and pharmacodynamics of a novel γ-aminobutyric acid (GABA) receptor potentiator, HSK3486, in Chinese patients with hepatic impairment.

Hu Y, Li X, Liu J, Chen H, Zheng W, Zhang H, Wu M, Li C, Zhu X, Lou J, Yan P, Wu N, Liu X, Ma S, Wang X, Ding Y, Xuan C. Hu Y, et al. Among authors: yan p. Ann Med. 2022 Dec;54(1):2769-2780. doi: 10.1080/07853890.2022.2129433. Ann Med. 2022. PMID: 36217101 Free PMC article. Clinical Trial.

4

Population total and unbound pharmacokinetics and pharmacodynamics of ciprofol and M4 in subjects with various renal functions.

Liu SB, Yao X, Tao J, Yang JJ, Zhao YY, Liu DW, Wang SY, Sun SK, Wang X, Yan PK, Wu N, Liu X, Zhang XJ, Tian X, Liu ZS. Liu SB, et al. Br J Clin Pharmacol. 2023 Mar;89(3):1139-1151. doi: 10.1111/bcp.15561. Epub 2022 Nov 4. Br J Clin Pharmacol. 2023. PMID: 36217805 Free article.

5

Dose decision of HSK7653 oral immediate release tablets in specific populations clinical trials based on mechanistic physiologically-based pharmacokinetic model.

Zhang M, Zhang S, Yu Z, Yao X, Lei Z, Yan P, Wu N, Wang X, Hu Q, Liu D. Zhang M, et al. Among authors: yan p. Eur J Pharm Sci. 2023 Oct 1;189:106553. doi: 10.1016/j.ejps.2023.106553. Epub 2023 Jul 31. Eur J Pharm Sci. 2023. PMID: 37532063 Free PMC article.

6

Population pharmacokinetic/pharmacodynamic modeling and exposure-response analysis of ciprofol in the induction and maintenance of general anesthesia in patients undergoing elective surgery: A prospective dose optimization study.

Liu L, Wang K, Yang Y, Hu M, Chen M, Liu X, Yan P, Wu N, Xiang X. Liu L, et al. Among authors: yan p. J Clin Anesth. 2024 Feb;92:111317. doi: 10.1016/j.jclinane.2023.111317. Epub 2023 Nov 15. J Clin Anesth. 2024. PMID: 37976683

7

Pharmacokinetics, pharmacodynamics, and safety of ciprofol emulsion in Chinese subjects with normal or impaired renal function.

Tao J, Liu S, Zhao YY, Qi L, Yan P, Wu N, Liu X, Liu D, Tian X. Tao J, et al. Among authors: yan p. Front Pharmacol. 2023 Nov 23;14:1260599. doi: 10.3389/fphar.2023.1260599. eCollection 2023. Front Pharmacol. 2023. PMID: 38074142 Free PMC article.

8

Pharmacokinetics and exposure-safety relationship of ciprofol for sedation in mechanically ventilated patients in the intensive care unit.

Liu L, Wang K, Sun Z, Yan P, Hu M, Liu X, Chen M, Wu N, Xiang X. Liu L, et al. Among authors: yan p. CPT Pharmacometrics Syst Pharmacol. 2024 May;13(5):823-836. doi: 10.1002/psp4.13121. Epub 2024 Mar 5. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38440939 Free PMC article.

9

Model informed drug development: HSK21542 PBPK model supporting dose decisions in specific populations.

Zhang M, Lei Z, Yao X, Zhang L, Yan P, Wu N, Chen M, Zhang F, Liu D. Zhang M, et al. Among authors: yan p. Eur J Pharm Sci. 2024 May 1;196:106763. doi: 10.1016/j.ejps.2024.106763. Epub 2024 Apr 8. Eur J Pharm Sci. 2024. PMID: 38599505 Free article.

10

Concentration-QTc Modeling of the DPP-4 Inhibitor HSK7653 in a First-in-Human Study of Chinese Healthy Volunteers.

Wang X, Liu H, Cui C, Niu X, Li H, Niu S, Yan P, Wu N, Li F, Wu Q, Chen K, Hu B, Liu D. Wang X, et al. Among authors: yan p. Clin Pharmacol Drug Dev. 2024 Jul;13(7):716-728. doi: 10.1002/cpdd.1418. Epub 2024 May 17. Clin Pharmacol Drug Dev. 2024. PMID: 38757550 Clinical Trial.

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