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Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region.
Eur Heart J. 2021 Dec 7;42(46):4743-4755. doi: 10.1093/eurheartj/ehab582.
Eur Heart J. 2021.
PMID: 34505893
Free PMC article.
Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1.
Heijman J, Spätjens RL, Seyen SR, Lentink V, Kuijpers HJ, Boulet IR, de Windt LJ, David M, Volders PG.
Heijman J, et al.
Circ Res. 2012 Jan 20;110(2):211-9. doi: 10.1161/CIRCRESAHA.111.249482. Epub 2011 Nov 17.
Circ Res. 2012.
PMID: 22095730
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Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of IKs, but preserved cAMP-dependent up-regulation.
Spätjens RL, Bébarová M, Seyen SR, Lentink V, Jongbloed RJ, Arens YH, Heijman J, Volders PG.
Spätjens RL, et al.
Cardiovasc Res. 2014 Oct 1;104(1):216-25. doi: 10.1093/cvr/cvu191. Epub 2014 Aug 18.
Cardiovasc Res. 2014.
PMID: 25139741
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Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.
Dirkx E, Gladka MM, Philippen LE, Armand AS, Kinet V, Leptidis S, El Azzouzi H, Salic K, Bourajjaj M, da Silva GJ, Olieslagers S, van der Nagel R, de Weger R, Bitsch N, Kisters N, Seyen S, Morikawa Y, Chanoine C, Heymans S, Volders PG, Thum T, Dimmeler S, Cserjesi P, Eschenhagen T, da Costa Martins PA, De Windt LJ.
Dirkx E, et al.
Nat Cell Biol. 2013 Nov;15(11):1282-93. doi: 10.1038/ncb2866. Epub 2013 Oct 27.
Nat Cell Biol. 2013.
PMID: 24161931
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