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Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
Rujas E, Leaman DP, Insausti S, Carravilla P, García-Porras M, Largo E, Morillo I, Sánchez-Eugenia R, Zhang L, Cui H, Iloro I, Elortza F, Julien JP, Eggeling C, Zwick MB, Caaveiro JMM, Nieva JL. Rujas E, et al. Among authors: morillo i. iScience. 2021 Aug 17;24(9):102987. doi: 10.1016/j.isci.2021.102987. eCollection 2021 Sep 24. iScience. 2021. PMID: 34505005 Free PMC article.