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The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment.
Björkman L, Mårtensson J, Winther M, Gabl M, Holdfeldt A, Uhrbom M, Bylund J, Højgaard Hansen A, Pandey SK, Ulven T, Forsman H, Dahlgren C. Björkman L, et al. Among authors: martensson j. Mol Cell Biol. 2016 Sep 26;36(20):2583-95. doi: 10.1128/MCB.00161-16. Print 2016 Oct 15. Mol Cell Biol. 2016. PMID: 27503855 Free PMC article.
Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R.
Sundqvist M, Christenson K, Holdfeldt A, Gabl M, Mårtensson J, Björkman L, Dieckmann R, Dahlgren C, Forsman H. Sundqvist M, et al. Among authors: martensson j. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):695-708. doi: 10.1016/j.bbamcr.2018.02.008. Epub 2018 Feb 22. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29477577 Free article.
Neutrophil recruitment to inflamed joints can occur without cellular priming.
Björkman L, Christenson K, Davidsson L, Mårtensson J, Amirbeagi F, Welin A, Forsman H, Karlsson A, Dahlgren C, Bylund J. Björkman L, et al. Among authors: martensson j. J Leukoc Biol. 2019 Jun;105(6):1123-1130. doi: 10.1002/JLB.3AB0918-369R. Epub 2018 Dec 20. J Leukoc Biol. 2019. PMID: 30570778
Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation mechanism.
Lind S, Holdfeldt A, Mårtensson J, Sundqvist M, Björkman L, Forsman H, Dahlgren C. Lind S, et al. Among authors: martensson j. FASEB J. 2019 Jun;33(6):6887-6903. doi: 10.1096/fj.201802309R. Epub 2019 Feb 26. FASEB J. 2019. PMID: 30808243
Further, the finding that an allosteric FFA2R modulator sensitizes not only the response induced by orthosteric FFA2R agonists, but also the response induced by ATP (P2Y(2)R-specific agonist) and formyl peptide receptor-specific agonists, violates the receptor restriction charact …
Further, the finding that an allosteric FFA2R modulator sensitizes not only the response induced by orthosteric FFA2R agonists, but also the …
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in neutrophils.
Lind S, Holdfeldt A, Mårtensson J, Sundqvist M, Kenakin TP, Björkman L, Forsman H, Dahlgren C. Lind S, et al. Among authors: martensson j. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118689. doi: 10.1016/j.bbamcr.2020.118689. Epub 2020 Feb 21. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 32092308 Free article.
451 results