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A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation.
Koshikawa N, Kida Y, Yasui N, Shinozaki Y, Tsuji K, Watanabe T, Lin J, Yamamoto S, Takenaga K, Nagase H. Koshikawa N, et al. Among authors: lin j. Biochem Biophys Res Commun. 2021 Oct 22;576:93-99. doi: 10.1016/j.bbrc.2021.08.088. Epub 2021 Aug 31. Biochem Biophys Res Commun. 2021. PMID: 34482029 Free article.
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