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Page 1
Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity.
Nascimento DC, Viacava PR, Ferreira RG, Damaceno MA, Piñeros AR, Melo PH, Donate PB, Toller-Kawahisa JE, Zoppi D, Veras FP, Peres RS, Menezes-Silva L, Caetité D, Oliveira AER, Castro ÍMS, Kauffenstein G, Nakaya HI, Borges MC, Zamboni DS, Fonseca DM, Paschoal JAR, Cunha TM, Quesniaux V, Linden J, Cunha FQ, Ryffel B, Alves-Filho JC. Nascimento DC, et al. Among authors: castro ims. Immunity. 2021 Sep 14;54(9):2024-2041.e8. doi: 10.1016/j.immuni.2021.08.005. Epub 2021 Sep 1. Immunity. 2021. PMID: 34473957 Free article.
In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.
Ten-Caten F, Gonzalez-Dias P, Castro Í, Ogava RLT, Giddaluru J, Silva JCS, Martins F, Gonçalves ANA, Costa-Martins AG, Araujo JD, Viegas AC, Cunha FQ, Farsky S, Bozza FA, Levin AS, Pannaraj PS, de Silva TI, Minoprio P, Pinheiro da Silva F, Andrade BB, Nakaya HI. Ten-Caten F, et al. Int J Infect Dis. 2021 Apr;105:579-587. doi: 10.1016/j.ijid.2021.03.016. Epub 2021 Mar 10. Int J Infect Dis. 2021. PMID: 33713813 Free PMC article.
Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology.
Silva CMS, Wanderley CWS, Veras FP, Gonçalves AV, Lima MHF, Toller-Kawahisa JE, Gomes GF, Nascimento DC, Monteiro VVS, Paiva IM, Almeida CJLR, Caetité DB, Silva JC, Lopes MIF, Bonjorno LP, Giannini MC, Amaral NB, Benatti MN, Santana RC, Damasceno LEA, Silva BMS, Schneider AH, Castro IMS, Silva JCS, Vasconcelos AP, Gonçalves TT, Batah SS, Rodrigues TS, Costa VF, Pontelli MC, Martins RB, Martins TV, Espósito DLA, Cebinelli GCM, da Fonseca BAL, Leiria LOS, Cunha LD, Arruda E, Nakaia HI, Fabro AT, Oliveira RDR, Zamboni DS, Louzada-Junior P, Cunha TM, Alves-Filho JCF, Cunha FQ. Silva CMS, et al. Among authors: castro ims. Crit Care. 2022 Jul 7;26(1):206. doi: 10.1186/s13054-022-04062-5. Crit Care. 2022. PMID: 35799268 Free PMC article.
Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children.
Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B, Ellis-Watson R, Tregoning JS, Bingle CD, Bogaert D, Clarke E, Ordovas-Montanes J, Jeffries D, Kampmann B, Nakaya HI, de Silva TI. Costa-Martins AG, et al. Cell Rep Med. 2021 Dec 9;2(12):100465. doi: 10.1016/j.xcrm.2021.100465. eCollection 2021 Dec 21. Cell Rep Med. 2021. PMID: 35028607 Free PMC article. Clinical Trial.
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19.
Hottz ED, Martins-Gonçalves R, Palhinha L, Azevedo-Quintanilha IG, de Campos MM, Sacramento CQ, Temerozo JR, Soares VC, Dias SSG, Teixeira L, Castro Í, Righy C, Souza TML, Kurtz P, Andrade BB, Nakaya HI, Monteiro RQ, Bozza FA, Bozza PT. Hottz ED, et al. Blood Adv. 2022 Sep 13;6(17):5085-5099. doi: 10.1182/bloodadvances.2021006680. Blood Adv. 2022. PMID: 35420680 Free PMC article.
PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease.
Duhalde Vega M, Olivera D, Gastão Davanzo G, Bertullo M, Noya V, Fabiano de Souza G, Primon Muraro S, Castro I, Arévalo AP, Crispo M, Galliussi G, Russo S, Charbonnier D, Rammauro F, Jeldres M, Alamón C, Varela V, Batthyany C, Bollati-Fogolín M, Oppezzo P, Pritsch O, Proença-Módena JL, Nakaya HI, Trias E, Barbeito L, Anegon I, Cuturi MC, Moraes-Vieira P, Segovia M, Hill M. Duhalde Vega M, et al. Sci Adv. 2022 Sep 23;8(38):eabn6545. doi: 10.1126/sciadv.abn6545. Epub 2022 Sep 21. Sci Adv. 2022. PMID: 36129987 Free PMC article.
SARS-CoV-2 uses CD4 to infect T helper lymphocytes.
Brunetti NS, Davanzo GG, de Moraes D, Ferrari AJR, Souza GF, Muraro SP, Knittel TL, Boldrini VO, Monteiro LB, Virgílio-da-Silva JV, Profeta GS, Wassano NS, Nunes Santos L, Carregari VC, Dias AHS, Veras FP, Tavares LA, Forato J, Castro IMS, Silva-Costa LC, Palma AC, Mansour E, Ulaf RG, Bernardes AF, Nunes TA, Ribeiro LC, Agrela MV, Moretti ML, Buscaratti LI, Crunfli F, Ludwig RG, Gerhardt JA, Munhoz-Alves N, Marques AM, Sesti-Costa R, Amorim MR, Toledo-Teixeira DA, Parise PL, Martini MC, Bispos-Dos-Santos K, Simeoni CL, Granja F, Silvestrini VC, de Oliveira EB, Faca VM, Carvalho M, Castelucci BG, Pereira AB, Coimbra LD, Dias MMG, Rodrigues PB, Gomes ABSP, Pereira FB, Santos LMB, Bloyet LM, Stumpf S, Pontelli MC, Whelan S, Sposito AC, Carvalho RF, Vieira AS, Vinolo MAR, Damasio A, Velloso L, Figueira ACM, da Silva LLP, Cunha TM, Nakaya HI, Marques-Souza H, Marques RE, Martins-de-Souza D, Skaf MS, Proenca-Modena JL, Moraes-Vieira PMM, Mori MA, Farias AS. Brunetti NS, et al. Among authors: castro ims. Elife. 2023 Jul 31;12:e84790. doi: 10.7554/eLife.84790. Elife. 2023. PMID: 37523305 Free PMC article.
Increased mTOR Signaling and Impaired Autophagic Flux Are Hallmarks of SARS-CoV-2 Infection.
Zambalde ÉP, Dias TL, Maktura GC, Amorim MR, Brenha B, Santos LN, Buscaratti L, Elston JGA, Mancini MCS, Pavan ICB, Toledo-Teixeira DA, Bispo-Dos-Santos K, Parise PL, Morelli AP, Silva LGSD, Castro ÍMS, Saccon TD, Mori MA, Granja F, Nakaya HI, Proenca-Modena JL, Marques-Souza H, Simabuco FM. Zambalde ÉP, et al. Among authors: castro ims. Curr Issues Mol Biol. 2022 Dec 31;45(1):327-336. doi: 10.3390/cimb45010023. Curr Issues Mol Biol. 2022. PMID: 36661509 Free PMC article.
17 results