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Structure of a mammalian ryanodine receptor.
Zalk R, Clarke OB, des Georges A, Grassucci RA, Reiken S, Mancia F, Hendrickson WA, Frank J, Marks AR. Zalk R, et al. Among authors: clarke ob. Nature. 2015 Jan 1;517(7532):44-9. doi: 10.1038/nature13950. Epub 2014 Dec 1. Nature. 2015. PMID: 25470061 Free PMC article.
Structural Basis for Gating and Activation of RyR1.
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J. des Georges A, et al. Among authors: clarke ob. Cell. 2016 Sep 22;167(1):145-157.e17. doi: 10.1016/j.cell.2016.08.075. Cell. 2016. PMID: 27662087 Free PMC article.
Structures of the colossal RyR1 calcium release channel.
Clarke OB, Hendrickson WA. Clarke OB, et al. Curr Opin Struct Biol. 2016 Aug;39:144-152. doi: 10.1016/j.sbi.2016.09.002. Epub 2016 Sep 27. Curr Opin Struct Biol. 2016. PMID: 27687475 Free PMC article. Review.
Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes.
Hartel AJW, Ong P, Schroeder I, Giese MH, Shekar S, Clarke OB, Zalk R, Marks AR, Hendrickson WA, Shepard KL. Hartel AJW, et al. Among authors: clarke ob. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1789-E1798. doi: 10.1073/pnas.1712313115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432144 Free PMC article.
Wavelet Denoising of High-Bandwidth Nanopore and Ion-Channel Signals.
Shekar S, Chien CC, Hartel A, Ong P, Clarke OB, Marks A, Drndic M, Shepard KL. Shekar S, et al. Among authors: clarke ob. Nano Lett. 2019 Feb 13;19(2):1090-1097. doi: 10.1021/acs.nanolett.8b04388. Epub 2019 Jan 7. Nano Lett. 2019. PMID: 30601669 Free PMC article.
Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.
Kushnir A, Todd JJ, Witherspoon JW, Yuan Q, Reiken S, Lin H, Munce RH, Wajsberg B, Melville Z, Clarke OB, Wedderburn-Pugh K, Wronska A, Razaqyar MS, Chrismer IC, Shelton MO, Mankodi A, Grunseich C, Tarnopolsky MA, Tanji K, Hirano M, Riazi S, Kraeva N, Voermans NC, Gruber A, Allen C, Meilleur KG, Marks AR. Kushnir A, et al. Among authors: clarke ob. Acta Neuropathol. 2020 Jun;139(6):1089-1104. doi: 10.1007/s00401-020-02150-w. Epub 2020 Mar 31. Acta Neuropathol. 2020. PMID: 32236737 Free PMC article.
69 results