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A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer.
Liu S, Li D, Liu J, Wang H, Horecny I, Shen R, Zhang R, Wu H, Hu Q, Zhao P, Zhang F, Yan Y, Feng J, Zhuang L, Li J, Zhang L, Tao W. Liu S, et al. Among authors: li d, li j. Onco Targets Ther. 2021 Aug 24;14:4561-4574. doi: 10.2147/OTT.S326178. eCollection 2021. Onco Targets Ther. 2021. PMID: 34466002 Free PMC article.
Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity.
Lu B, Liu D, Gui B, Gou J, Dong H, Hu Q, Feng J, Mao Y, Shen X, Wang S, Zhang C, Shen R, Yan Y, Chen L, Wang H, Li D, Zhang J, Zhang M, Zhang R, Bai C, He F, Tao W, Liu S. Lu B, et al. Among authors: li d. J Med Chem. 2021 Oct 28;64(20):14983-14996. doi: 10.1021/acs.jmedchem.1c00828. Epub 2021 Oct 13. J Med Chem. 2021. PMID: 34643383
SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Song C, Liu D, Liu S, Li D, Horecny I, Zhang X, Li P, Chen L, Miller M, Chowdhury R, Issa M, Shen R, Yan Y, Zhang F, Zhang L, Zhang L, Bai C, Feng J, Zhuang L, Zhang R, Li J, Wilkinson H, Liu J, Tao W. Song C, et al. Among authors: li d, li j, li p. Sci Rep. 2022 May 20;12(1):8579. doi: 10.1038/s41598-022-12449-1. Sci Rep. 2022. PMID: 35595822 Free PMC article.
Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways.
Zhou Y, Li X, Shen R, Wang X, Zhang F, Liu S, Li D, Liu J, Li P, Yan Y, Dong P, Zhang Z, Wu H, Zhuang L, Chowdhury R, Miller M, Issa M, Mao Y, Chen H, Feng J, Li J, Bai C, He F, Tao W. Zhou Y, et al. Among authors: li d, li j, li x, li p. Front Immunol. 2022 May 20;13:884399. doi: 10.3389/fimmu.2022.884399. eCollection 2022. Front Immunol. 2022. PMID: 35693820 Free PMC article.
Discovery of Isoindoline Amide Derivatives as Potent and Orally Bioavailable ADAMTS-4/5 Inhibitors for the Treatment of Osteoarthritis.
Zhao P, Liu D, Song C, Li D, Zhang X, Horecny I, Zhang F, Yan Y, Zhuang L, Li J, Liu S, Mao Y, Feng J, Liu J, Tao W. Zhao P, et al. Among authors: li d, li j. ACS Pharmacol Transl Sci. 2022 Jun 22;5(7):458-467. doi: 10.1021/acsptsci.2c00023. eCollection 2022 Jul 8. ACS Pharmacol Transl Sci. 2022. PMID: 35837136 Free PMC article.
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