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Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.
Friedrich C, Taggenbrock RLRE, Doucet-Ladevèze R, Golda G, Moenius R, Arampatzi P, Kragten NAM, Kreymborg K, Gomez de Agüero M, Kastenmüller W, Saliba AE, Grün D, van Gisbergen KPJM, Gasteiger G. Friedrich C, et al. Nat Immunol. 2021 Oct;22(10):1256-1267. doi: 10.1038/s41590-021-01013-0. Epub 2021 Aug 30. Nat Immunol. 2021. PMID: 34462601 Free PMC article.
A central role for Notch in effector CD8(+) T cell differentiation.
Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AH, Kaech SM, Blander JM, van Gisbergen K, Amsen D. Backer RA, et al. Nat Immunol. 2014 Dec;15(12):1143-51. doi: 10.1038/ni.3027. Epub 2014 Oct 26. Nat Immunol. 2014. PMID: 25344724 Free PMC article.
Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans.
Vieira Braga FA, Hertoghs KM, Kragten NA, Doody GM, Barnes NA, Remmerswaal EB, Hsiao CC, Moerland PD, Wouters D, Derks IA, van Stijn A, Demkes M, Hamann J, Eldering E, Nolte MA, Tooze RM, ten Berge IJ, van Gisbergen KP, van Lier RA. Vieira Braga FA, et al. Eur J Immunol. 2015 Oct;45(10):2945-58. doi: 10.1002/eji.201545650. Epub 2015 Sep 7. Eur J Immunol. 2015. PMID: 26179882 Free article.
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.
Mackay LK, Minnich M, Kragten NA, Liao Y, Nota B, Seillet C, Zaid A, Man K, Preston S, Freestone D, Braun A, Wynne-Jones E, Behr FM, Stark R, Pellicci DG, Godfrey DI, Belz GT, Pellegrini M, Gebhardt T, Busslinger M, Shi W, Carbone FR, van Lier RA, Kallies A, van Gisbergen KP. Mackay LK, et al. Science. 2016 Apr 22;352(6284):459-63. doi: 10.1126/science.aad2035. Science. 2016. PMID: 27102484
65 results