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miR-421 up-regulation by the oleanolic acid derivative K73-03 regulates epigenetically SPINK1 transcription in pancreatic cancer cells leading to metabolic changes and enhanced apoptosis.
Shopit A, Li X, Tang Z, Awsh M, Shobet L, Niu M, Wang H, Mousa H, Alshwmi M, Tesfaldet T, Gamallat Y, Li H, Chu P, Ahmad N, Jamalat Y, Ai J, Qaed E, Almoiliqy M, Wang S, Tang Z. Shopit A, et al. Among authors: awsh m. Pharmacol Res. 2020 Nov;161:105130. doi: 10.1016/j.phrs.2020.105130. Epub 2020 Aug 17. Pharmacol Res. 2020. PMID: 32818653
Corrigendum "Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells" [Phytomedicine 2021:91:153711].
Shopit A, Li X, Wang S, Awsh M, Safi M, Chu P, Jia J, Al-Radhi M, Baldi S, Wang F, Fang J, Peng J, Ma X, Tang Z, Shu X. Shopit A, et al. Among authors: awsh m. Phytomedicine. 2025 Jan;136:156301. doi: 10.1016/j.phymed.2024.156301. Epub 2024 Dec 12. Phytomedicine. 2025. PMID: 39672684 No abstract available.