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USP7 is a SUMO deubiquitinase essential for DNA replication.
Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O. Lecona E, et al. Nat Struct Mol Biol. 2016 Apr;23(4):270-7. doi: 10.1038/nsmb.3185. Epub 2016 Mar 7. Nat Struct Mol Biol. 2016. PMID: 26950370 Free PMC article.
USP7 limits CDK1 activity throughout the cell cycle.
Galarreta A, Valledor P, Ubieto-Capella P, Lafarga V, Zarzuela E, Muñoz J, Malumbres M, Lecona E, Fernandez-Capetillo O. Galarreta A, et al. Among authors: lecona e. EMBO J. 2021 Jun 1;40(11):e99692. doi: 10.15252/embj.201899692. Epub 2021 Apr 15. EMBO J. 2021. PMID: 33856059 Free PMC article.
USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork.
Franz A, Valledor P, Ubieto-Capella P, Pilger D, Galarreta A, Lafarga V, Fernández-Llorente A, de la Vega-Barranco G, den Brave F, Hoppe T, Fernandez-Capetillo O, Lecona E. Franz A, et al. Among authors: lecona e. Cell Rep. 2021 Oct 12;37(2):109819. doi: 10.1016/j.celrep.2021.109819. Cell Rep. 2021. PMID: 34644576 Free PMC article.
Replication stress and cancer: it takes two to tango.
Lecona E, Fernández-Capetillo O. Lecona E, et al. Exp Cell Res. 2014 Nov 15;329(1):26-34. doi: 10.1016/j.yexcr.2014.09.019. Epub 2014 Sep 26. Exp Cell Res. 2014. PMID: 25257608 Free PMC article. Review.
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.
Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez-Acebes S, Lecona E, Murga M, Méndez J, Blasco MA, Fernandez-Capetillo O. Jacome A, et al. Among authors: lecona e. EMBO J. 2015 Nov 3;34(21):2604-19. doi: 10.15252/embj.201591829. Epub 2015 Oct 6. EMBO J. 2015. PMID: 26443207 Free PMC article.
POLD3 Is Haploinsufficient for DNA Replication in Mice.
Murga M, Lecona E, Kamileri I, Díaz M, Lugli N, Sotiriou SK, Anton ME, Méndez J, Halazonetis TD, Fernandez-Capetillo O. Murga M, et al. Among authors: lecona e. Mol Cell. 2016 Sep 1;63(5):877-83. doi: 10.1016/j.molcel.2016.07.007. Epub 2016 Aug 11. Mol Cell. 2016. PMID: 27524497 Free PMC article.
Targeting ATR in cancer.
Lecona E, Fernandez-Capetillo O. Lecona E, et al. Nat Rev Cancer. 2018 Sep;18(9):586-595. doi: 10.1038/s41568-018-0034-3. Nat Rev Cancer. 2018. PMID: 29899559 Review.
36 results