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Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.
Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R. Chia S, et al. Among authors: lezhava a. Nat Commun. 2017 Sep 5;8(1):435. doi: 10.1038/s41467-017-00451-5. Nat Commun. 2017. PMID: 28874669 Free PMC article.
Genome-wide identification of natural RNA aptamers in prokaryotes and eukaryotes.
Tapsin S, Sun M, Shen Y, Zhang H, Lim XN, Susanto TT, Yang SL, Zeng GS, Lee J, Lezhava A, Ang EL, Zhang LH, Wang Y, Zhao H, Nagarajan N, Wan Y. Tapsin S, et al. Among authors: lezhava a. Nat Commun. 2018 Mar 29;9(1):1289. doi: 10.1038/s41467-018-03675-1. Nat Commun. 2018. PMID: 29599443 Free PMC article.
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma.
Yao X, Hong JH, Nargund AM, Ng MSW, Heng HL, Li Z, Guan P, Sugiura M, Chu PL, Wang LC, Ye X, Qu J, Kwek XY, Lim JCT, Ooi WF, Koh J, Wang Z, Pan YF, Ong YS, Tan KY, Goh JY, Ng SR, Pignata L, Huang D, Lezhava A, Tay ST, Lee M, Yeo XH, Tam WL, Rha SY, Li S, Guccione E, Futreal A, Tan J, Yeong JPS, Hong W, Yauch R, Chang KT, Sobota RM, Tan P, Teh BT. Yao X, et al. Among authors: lezhava a. Nat Cell Biol. 2023 May;25(5):765-777. doi: 10.1038/s41556-023-01122-y. Epub 2023 Apr 24. Nat Cell Biol. 2023. PMID: 37095322
Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723.
Sinha S, Nge CE, Leong CY, Ng V, Crasta S, Alfatah M, Goh F, Low KN, Zhang H, Arumugam P, Lezhava A, Chen SL, Kanagasundaram Y, Ng SB, Eisenhaber F, Eisenhaber B. Sinha S, et al. Among authors: lezhava a. BMC Genomics. 2019 May 14;20(1):374. doi: 10.1186/s12864-019-5762-6. BMC Genomics. 2019. PMID: 31088369 Free PMC article.
Technical Validation of a Next-Generation Sequencing Assay for Detecting Actionable Mutations in Patients with Gastrointestinal Cancer.
Wang SR, Malik S, Tan IB, Chan YS, Hoi Q, Ow JL, He CZ, Ching CE, Poh DYS, Seah HM, Cheung KHT, Perumal D, Devasia AG, Pan L, Ang S, Lee SE, Ten R, Chua C, Tan DSW, Qu JZZ, Bylstra YM, Lim L, Lezhava A, Ng PC, Wong CW, Lim T, Tan P. Wang SR, et al. Among authors: lezhava a. J Mol Diagn. 2016 May;18(3):416-424. doi: 10.1016/j.jmoldx.2016.01.006. Epub 2016 Mar 9. J Mol Diagn. 2016. PMID: 26970585 Free article.
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P. Yao X, et al. Among authors: lezhava a. Cancer Discov. 2017 Nov;7(11):1284-1305. doi: 10.1158/2159-8290.CD-17-0375. Epub 2017 Sep 11. Cancer Discov. 2017. PMID: 28893800
Identification and engineering of 32 membered antifungal macrolactone notonesomycins.
Goh F, Zhang MM, Lim TR, Low KN, Nge CE, Heng E, Yeo WL, Sirota FL, Crasta S, Tan Z, Ng V, Leong CY, Zhang H, Lezhava A, Chen SL, Hoon SS, Eisenhaber F, Eisenhaber B, Kanagasundaram Y, Wong FT, Ng SB. Goh F, et al. Among authors: lezhava a. Microb Cell Fact. 2020 Mar 19;19(1):71. doi: 10.1186/s12934-020-01328-x. Microb Cell Fact. 2020. PMID: 32192516 Free PMC article.
61 results