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MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Müller A, Spahn M, Seitz AK, Frank T, Marouf H, Büchel G, Eckstein M, Kübler H, Eilers M, Saar M, Junker K, Röhrig F, Kneitz B, Rosenfeldt MT, Schulze A. Kalogirou C, et al. Among authors: rosenfeldt mt. Nat Commun. 2021 Aug 20;12(1):5066. doi: 10.1038/s41467-021-25325-9. Nat Commun. 2021. PMID: 34417456 Free PMC article.
Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
Kaymak I, Maier CR, Schmitz W, Campbell AD, Dankworth B, Ade CP, Walz S, Paauwe M, Kalogirou C, Marouf H, Rosenfeldt MT, Gay DM, McGregor GH, Sansom OJ, Schulze A. Kaymak I, et al. Among authors: rosenfeldt mt. Cancer Res. 2020 Jan 15;80(2):189-203. doi: 10.1158/0008-5472.CAN-19-0650. Epub 2019 Nov 19. Cancer Res. 2020. PMID: 31744820
Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma.
Roeschert I, Poon E, Henssen AG, Garcia HD, Gatti M, Giansanti C, Jamin Y, Ade CP, Gallant P, Schülein-Völk C, Beli P, Richards M, Rosenfeldt M, Altmeyer M, Anderson J, Eggert A, Dobbelstein M, Bayliss R, Chesler L, Büchel G, Eilers M. Roeschert I, et al. Nat Cancer. 2021 Mar;2(3):312-326. doi: 10.1038/s43018-020-00171-8. Epub 2021 Feb 11. Nat Cancer. 2021. PMID: 33768209 Free PMC article.
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
Rudalska R, Harbig J, Snaebjornsson MT, Klotz S, Zwirner S, Taranets L, Heinzmann F, Kronenberger T, Forster M, Cui W, D'Artista L, Einig E, Hinterleitner M, Schmitz W, Dylawerska A, Kang TW, Poso A, Rosenfeldt MT, Malek NP, Bitzer M, Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D. Rudalska R, et al. Among authors: rosenfeldt mt. Nat Cancer. 2021 Feb;2(2):201-217. doi: 10.1038/s43018-020-00168-3. Epub 2021 Feb 15. Nat Cancer. 2021. PMID: 35122079
Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice.
Mainz L, Sarhan MAFE, Roth S, Sauer U, Kalogirou C, Eckstein M, Gerhard-Hartmann E, Seibert HD, Voelker HU, Geppert C, Rosenwald A, Eilers M, Schulze A, Diefenbacher M, Rosenfeldt MT. Mainz L, et al. Among authors: rosenfeldt mt. Autophagy. 2022 Dec;18(12):2880-2893. doi: 10.1080/15548627.2022.2052588. Epub 2022 Mar 28. Autophagy. 2022. PMID: 35343375 Free PMC article.
RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells.
Otto C, Kastner C, Schmidt S, Uttinger K, Baluapuri A, Denk S, Rosenfeldt MT, Rosenwald A, Roehrig F, Ade CP, Schuelein-Voelk C, Diefenbacher ME, Germer CT, Wolf E, Eilers M, Wiegering A. Otto C, et al. Among authors: rosenfeldt mt. Mol Oncol. 2022 Aug;16(15):2788-2809. doi: 10.1002/1878-0261.13265. Epub 2022 Jul 1. Mol Oncol. 2022. PMID: 35673898 Free PMC article.
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer.
Maier CR, Hartmann O, Prieto-Garcia C, Al-Shami KM, Schlicker L, Vogel FCE, Haid S, Klann K, Buck V, Münch C, Schmitz W, Einig E, Krenz B, Calzado MA, Eilers M, Popov N, Rosenfeldt MT, Diefenbacher ME, Schulze A. Maier CR, et al. Among authors: rosenfeldt mt. Cell Death Differ. 2023 Jul;30(7):1710-1725. doi: 10.1038/s41418-023-01173-6. Epub 2023 May 18. Cell Death Differ. 2023. PMID: 37202505 Free PMC article.
PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma.
Gaballa A, Gebhardt-Wolf A, Krenz B, Mattavelli G, John M, Cossa G, Andreani S, Schülein-Völk C, Montesinos F, Vidal R, Kastner C, Ade CP, Kneitz B, Gasteiger G, Gallant P, Rosenfeldt M, Riedel A, Eilers M. Gaballa A, et al. Nat Commun. 2024 Feb 16;15(1):1446. doi: 10.1038/s41467-024-45760-8. Nat Commun. 2024. PMID: 38365788 Free PMC article.
44 results