Sun J - Search Results

1

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design.

Lu S, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun J, Zhang J. Lu S, et al. Among authors: sun j. Nat Commun. 2021 Aug 5;12(1):4721. doi: 10.1038/s41467-021-25020-9. Nat Commun. 2021. PMID: 34354057 Free PMC article.

2

Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).

Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Strachan RT, et al. Among authors: sun jp. J Biol Chem. 2014 May 16;289(20):14211-24. doi: 10.1074/jbc.M114.548131. Epub 2014 Mar 25. J Biol Chem. 2014. PMID: 24668815 Free PMC article.

3

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.

Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY, Sun JP. Yang F, et al. Nat Commun. 2015 Sep 8;6:8202. doi: 10.1038/ncomms9202. Nat Commun. 2015. PMID: 26347956 Free PMC article.

4

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.

Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu CX, Xiao P, Liu CY, Thomsen AR, Joseph Cahill T 3rd, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP. Liu CH, et al. Nat Commun. 2017 Feb 9;8:14335. doi: 10.1038/ncomms14335. Nat Commun. 2017. PMID: 28181498 Free PMC article.

5

Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model.

Yang Z, Yang F, Zhang D, Liu Z, Lin A, Liu C, Xiao P, Yu X, Sun JP. Yang Z, et al. Mol Pharmacol. 2017 Sep;92(3):201-210. doi: 10.1124/mol.116.107839. Epub 2017 Feb 28. Mol Pharmacol. 2017. PMID: 28246190 Review.

6

Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.

Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W. Li T, et al. Among authors: sun j. Nat Commun. 2018 Jan 2;9(1):11. doi: 10.1038/s41467-017-02401-7. Nat Commun. 2018. PMID: 29296021 Free PMC article.

7

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.

Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D, Yu X, Sun JP. Zhang DL, et al. Among authors: sun yj, sun jp. Elife. 2018 Feb 2;7:e33432. doi: 10.7554/eLife.33432. Elife. 2018. PMID: 29393851 Free PMC article.

8

Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents.

Li N, Yang Z, Li Q, Yu Z, Chen X, Li JC, Li B, Ning SL, Cui M, Sun JP, Yu X. Li N, et al. Cell Death Dis. 2018 Jun 7;9(6):682. doi: 10.1038/s41419-018-0741-4. Cell Death Dis. 2018. PMID: 29880854 Free PMC article.

9

Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.

Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP, Wang J. Yang F, et al. Among authors: sun jp. Nat Chem Biol. 2018 Sep;14(9):876-886. doi: 10.1038/s41589-018-0115-3. Epub 2018 Aug 17. Nat Chem Biol. 2018. PMID: 30120361

10

Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22.

Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun J, Yu X. Li K, et al. Among authors: sun j. J Biol Chem. 2019 May 24;294(21):8653-8663. doi: 10.1074/jbc.RA118.007129. Epub 2019 Apr 12. J Biol Chem. 2019. PMID: 30979725 Free PMC article.

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